Effects of low-calorie and different weight-maintenance diets on IgG glycome composition

Deriš et al.

Frontiers in Immunology

Objective

The study assessed whether caloric restriction–induced weight loss followed by various maintenance diets improves IgG glycans and reduces chronic inflammation.

Methods

938 individuals followed a low-calorie diet of 800 kcal/day for 8 weeks. Afterward, they were assigned to one of five maintenance diets that varied in protein content and glycemic index.

Results

Following the low-calorie diet, participants achieved the target weight loss of 8% and showed significant improvements in their IgG glycan profiles, indicating a reduction in chronic inflammation.

However, with the maintenance diets, we didn’t see clear trends, as different people responded differently to all five diets. On each maintenance diet, some individuals improved while others worsened, highlighting that there is no diet that works for everybody.

Conclusion

These results show that caloric restriction and the resulting weight loss can positively influence immune system function and reduce chronic inflammation.

The varied responses to the five maintenance diets support the idea that there is no one-size-fits-all approach, and a personalized strategy is needed when it comes to diets aimed at supporting long-term health.

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