Jurić et al.
Aging (Albany NY)
Assess the impact of estrogen on biological aging in women.
Menopause was experimentally induced in 36 healthy young women by suppressing their natural estrogen production. Participants were then randomized to receive either transdermal estrogen therapy or placebo.
Women who had their estrogen production suppressed showed an average increase of 9.1 years in their biological age. This increase was completely abolished in women who received estrogen supplementation.
Estrogen depletion, similar to what occurs in menopause, leads to a sharp rise in biological age. However, estrogen supplementation, as seen in hormone replacement therapy, counteracts this effect, highlighting its potential to reduce biological age.
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