ESTROGEN STUDY
Effects of estradiol on biological age measured using the glycan age index
Jurić et al.
Aging (Albany NY)
1
Objective
Assess the impact of estrogen on biological aging in women.
2
Methods
Menopause was experimentally induced in 36 healthy young women by suppressing their natural estrogen production. Participants were then randomized to receive either transdermal estrogen therapy or placebo.
3
Results
Women who had their estrogen production suppressed showed an average increase of 9.1 years in their biological age. This increase was completely abolished in women who received estrogen supplementation.
4
Conclusion
Estrogen depletion, similar to what occurs in menopause, leads to a sharp rise in biological age. However, estrogen supplementation, as seen in hormone replacement therapy, counteracts this effect, highlighting its potential to reduce biological age.
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