Glycan Research Case Studies

CASE STUDIES

Completed studies

The following case studies demonstrate the power and versatility of glycan analysis in modern research. Discover how glycans are being used by leading scientists to generate novel insights and measure the impact of specific hormones, supplements, and lifestyle interventions on biological age.

Testosterone and Metformin Study

Effects of testosterone and metformin on the GlycanAge index of biological age and the composition of the IgG glycome

A study explored how metformin and testosterone affect biological age in healthy overweight men, using glycan-based insights.

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Estrogen Study

Effects of estradiol on biological age measured using the glycan age index

A study investigating changes in IgG glycans in women following estrogen suppression and their response to subsequent estrogen reintroduction.

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NAD+ Study

The use of a systems approach to increase NAD+ in human participants

A study evaluating the effectiveness of NUCHIDO TIME+ in increasing NAD+ levels and its impact on biological aging and IgG glycans.

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Diet Study

Effects of low-calorie and different weight-maintenance diets on IgG glycome composition

A study explored how caloric restriction–induced weight loss and various weight maintenance diets affect IgG glycans and chronic inflammation.

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Biomarker Discovery

N-Glycosylation Profiles of Immunoglobulin G and Future Cardiovascular Events

A study investigating the potential of IgG glycans in predicting future cardiovascular events.

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Biomarker Discovery

Plasma N-glycome shows continuous deterioration as the diagnosis of insulin resistance approaches

A study investigating changes in plasma glycosylation as potential early biomarkers for predicting insulin resistance and type 2 diabetes.

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ONGOING RESEARCH

Ongoing studies

Our spirit of discovery is ongoing. We are continuously collaborating with partners to explore new frontiers in glycan science and healthy aging. Below is a selection of research currently underway.

GLP-1 Therapy

Impact of Tirzepatide on IgG Glycosylation and Biological Age

Evaluating the 3-month impact of tirzepatide (Mounjaro), a GLP-1/GIP receptor agonist, on biological age in overweight and obese participants.

GLP-1 Therapy

Impact of Semaglutide and Tirzepatide on Biological Age

Evaluating the 6-month impact of GLP-1 therapies (Semaglutide and Tirzepatide) on IgG glycans and biological age.

Ovarian Aging

Biological and Ovarian Aging in Women Undergoing IVF

Investigating whether IgG glycosylation patterns and biological age can track ovarian aging in women undergoing in vitro fertilization (IVF).

Peptides

Impact of Thymus Bioregulator Peptide on Biological Age

Investigating the 3-month impact of thymus peptide on IgG glycans and biological age.

ACADEMIC AND COMMERCIAL PARTNERS

Our Research Collaborations

Our science is grounded in over three decades of glycan research led by Professor Gordan Lauc and realized through the work of our laboratory partner, Genos.

The Genos team, together with academic collaborators, has published more than 350 peer-reviewed articles and analyzed over 300,000 samples, accounting for more than 80% of all high-throughput glycan analyses worldwide.

This robust scientific foundation supports the GlycanAge test, with all analyses performed in Genos’s state-of-the-art laboratory to ensure the highest standards of rigor and expertise.

Publications

Let's Discuss Your Research

Have a project in mind or want to learn more about how glycan analysis can enhance your work? Our scientific team is ready to explore the possibilities with you.

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