Publications
Peer-reviewed glycan research behind GlycanAge
GlycanAge is based on research performed on over 300,000 people. These findings
identified that glycans change 7-10 years before the disease is first diagnosed. Glycans
also respond to lifestyle interventions within a short timeframe, providing valuable
insights.
If you’re interested in including glycans in your research, check out
our GlycanAge for Research page to see how we can collaborate.
You can see all of our publications in chronological
order below.
Our research team
2024
Variability of human Alpha-1-acid glycoprotein N-glycome in a Caucasian population Frano Vučković, Mislav Novokmet,Frano Vučković, Gordan Lauc, at al. • GLYCOBIOLOGY N-Glycosylation Profiles of Immunoglobulin G and Future Cardiovascular Events Hoshi RA, et al. • Circulation Research Functional Signature of LRP4 Antibodies in Myasthenia Gravis Omar Chuquisana, at al. • Neurology Journals Influence of Desialylation on the Drug Binding Affinity of Human Alpha-1-Acid Glycoprotein Assessed by Microscale Thermophoresis Šeba T, et al. • Pharmaceutics The use of a systems approach to increase NAD+ in human participants Henderson JD, et al. • npj Aging MMP3 single-nucleotide polymorphisms are associated with noncontact ACL injuries in competing high-level athletes Šimunić-Briški N, et al. • Journal of Orthopaedic Research Anastrozole and Tamoxifen Impact on IgG Glycome Composition Dynamics in Luminal A and Luminal B Breast Cancers Rapčan B, et al. • Antibodies Alterations in plasma protein N-glycosylation after caloric restriction and bariatric surgery Štambuk T, et al. • Surgery for Obesity and Related Diseases
2023
Plasma protein N-glycome composition associates with postprandial lipaemic response Louca P, et al. • BMC Medicine Total serum N-glycans associate with response to immune checkpoint inhibition therapy and survival in patients with advanced melanoma Visconti A, et al. • BMC Cancer Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels Murray A, et al. • eBioMedicine Human complement component C3 N-glycome changes in type 1 diabetes complications Šoić D, et al. • Frontiers in Endocrinology IgG N-glycans are associated with prevalent and incident complications of type 2 diabetes Memarian E, et al. • Diabetes/Metabolism Research and Reviews Comparative analysis of transferrin and IgG N-glycosylation in two human populations Trbojević-Akmačić I, et al. • Communications Biology High-throughput immunoaffinity enrichment and N-glycan analysis of human plasma haptoglobin Šimunović J., et al. • Biotechnology and Bioengineering Storage stability and HILIC-UHPLC-FLR analysis of immunoglobulin G N-glycome from saliva Radovani B, et al. • Analytical and Bioanalytical Chemistry The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder Tudor L, et al. • International Journal of Molecular Sciences Periodic Changes in the N-Glycosylation of Immunoglobulin G During the Menstrual Cycle Jurić J, et al. • Engineering Higher MRI lesion load in multiple sclerosis is related to the N-glycosylation changes of cerebrospinal fluid immunoglobulin G Turčić A, et al. • Multiple Sclerosis and Related Disorders Anti-TNF Biologicals Enhance the Anti-Inflammatory Properties of IgG N-Glycome in Crohn's Disease Hanić M, et al. • Biomolecules The N-Glycosylation of Total Plasma Proteins and IgG in Atrial Fibrillation Branimir Plavša B, et al. • Biomolecules IgG N-Glycosylation Is Altered in Coronary Artery Disease Radovani B, et al. • Biomolecules Mapping of the gene network that regulates glycan clock of ageing Azra Frkatović-Hodžić A, et al. • Aging Regular moderate physical exercise decreases Glycan Age index of biological age and reduces inflammatory potential of Immunoglobulin G Šimunić-Briški N, et al. • Glycoconjugate Journal Can we suppress chronic systemic inflammation and postpone age-related diseases by targeting the IgG glycome? Lauc G, et al. • Expert Opinion on Therapeutic Targets Reversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction Horvath S, et al. • Geroscience IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy Shkunnikova S, et al. • Biotechnology Advances Not-So-Sweet Dreams: Plasma and IgG N-Glycome in the Severe Form of the Obstructive Sleep Apnea Doris Plećaš et al. • Biomolecules IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy Sofia Shkunnikova et al. • ScienceDirect Human-specific features and developmental dynamics of the brain N-glycome Thomas S Klarić et al. • NCBI PubMed
2022
Blood plasma/IgG N-glycome biosignatures associated with major depressive disorder symptom severity and the antidepressant response Gordan Lauc et al. • Nature Immunoglobulin G N-Glycosylation Signatures in Incident Type 2 Diabetes and Cardiovascular Disease Gordan Lauc et al. • Diabetes Journals Glycosylation Profile of Immunoglobulin G and Incident Cardiovascular Events: Secondary Analysis of Two Randomized Clinical Trials Gordan Lauc et al. • AHA Journals Heritability of the glycan clock of biological age Anika Mijakovac et al. • Frontiers Differences in Immunoglobulin G Glycosylation Between Influenza and COVID-19 Patients Marina Kljaković-Gašpić Batinjan et al. • Sience Direct Effects of low-calorie and different weight-maintenance diets on IgG glycome composition Helena Deriš et al. • Frontiers A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk Azra Frkatović et al. • Aging High-throughput human complement C3 N-glycoprofiling identifies markers of early onset type 1 diabetes mellitus in children Dinko Šoić et al • MCP Immunoglobulin G glycans – Biomarkers and molecular effectors of aging Jasminka Krištić et al • ScienceDirect Baseline IgG-Fc N-glycosylation profile is associated with long-term outcome in a cohort of early inflammatory arthritis patients Sénard et al • BMC Arthritis Research & Therapy Distinct Longitudinal Changes in Immunoglobulin G N-Glycosylation Associate with Therapy Response in Chronic Inflammatory Diseases Jerko Štambuk et al • MDPI, International Journal of Molecular Sciences The dynamic brain N-glycome Thomas S. Klarić & Gordan Lauc • Springer Fucosylated AGP glycopeptides as biomarkers of HNF1A-Maturity onset diabetes of the young Marko Tijardovic et al. • Elsevier A Transient Expression System with Stably Integrated CRISPR-dCas9 Fusions for Regulation of Genes Involved in Immunoglobulin G Glycosylation Gordan Lauc, et al. • The CRISPR Journal Immunoglobulin G glycome composition in transition from premenopause to postmenopause Gordan Lauc et al. • iScience Altered IgG glycosylation at COVID-19 diagnosis predicts disease severity Gordan Lauc, et al. • European Journal of Immunology Developments and perspectives in high-throughput protein glycomics: enabling the analysis of thousands of samples Gordan Lauc, PhD et al. • Oxford Academic N-Glycosylation and Inflammation; the Not-So-Sweet Relation Ivan Gudelj and Barbara Radovani • Frontiers High-Throughput Glycomic Methods Gordan Lauc et al. • Chemical Reviews IgG N-glycome changes during the course of severe COVID-19: An observational study Tea Petrović, et al. • The Lancet
2021
N-glycosylation of immunoglobulin G predicts incident hypertension Gordan Lauc et al. • Journal of hypertension Plasma N-glycome shows continuous deterioration as the diagnosis of insulin resistance approaches Ana Cvetko, et al. • BMJ Journals A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection Tanya M. Monaghan, et al. • Cells Investigation of the causal relationships between human IgG N-glycosylation and twelve common diseases associated with changes in the IgG N-glycome Olga O Zaytseva, et al. • Oxford Academic Immunoglobulin G glycome composition in transition from pre-menopause to menopause Domagoj Kifer, et al. • MedRxiv Targeting B cells in the pre-phase of systemic autoimmunity globally interferes with autoimmune pathology Anja Werner, et al. • Cell Effects of Estradiol on Immunoglobulin G Glycosylation: Mapping of the Downstream Signaling Mechanism Anika Mijakovac, et al. • Frontiers in Immunology Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India Tanya M. Monaghan, et al. • Microorganisms Systems Glycobiology: Immunoglobulin G Glycans as Biomarkers and Functional Effectors in Aging and Diseases Marija Martinić Kavur, Gordan Lauc and Marija Pezer • ScienceDirect Extensive weight loss reduces glycan age by altering IgG N-glycosylation Valentina L Greto, et al. • International Journal of Obesity
2020
Effects of estradiol on biological age measured using the glycan age index Julija Jurić, et al. • Ageing Composition of the immunoglobulin G glycome associates with the severity of COVID-19 Tea Petrović, et al. • Glycobiology Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases Lucija Klarić, et al. • Science Advances Minimal B Cell Extrinsic IgG Glycan Modifications of Pro- and Anti-Inflammatory IgG Preparations in vivo Anja Schaffert, et al. • Frontiers in Immunology Plasma N-Glycans as Emerging Biomarkers of Cardiometabolic Risk: A Prospective Investigation in the EPIC-Potsdam Cohort Study Clemens Wittenbecher, et al. • Diabetes Care Global variability of the human IgG glycome. Jerko Štambuk, et al. • Ageing N-glycans as functional effectors of genetic and epigenetic disease risk Tamara Štambuk et al. • Science direct Biomarkers of biological age as predictors of COVID-19 disease severity Gordan Lauc, David Sinclair • Ageing Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases Tiphaine C. Martin, et al. • Mollecular & Cellular proteomics Searching for glycomic biomarkers for predicting resilience and vulnerability in a rat model of posttraumatic stress disorder Csilla Lea Fazekasab, et al. • The International Journal on the Biology of Stress
2019
Association of the IgG N-glycome with the course of kidney function in type 2 diabetes Sunny S Singh, et al. • BMJ Journals Translational glycobiology: from bench to bedside. Axford J, et al. • Journal of Royal Society of Medicine Supplementation with the Sialic Acid Precursor N-acetyl-D-Mannosamine Breaks the Link Between Obesity and Hypertension. Jun P, et al. • Circulation Inflammatory bowel disease - glycomics perspective. Wang H, et al. • Biochimica et Biophysica Acta Type 2 Diabetes Mellitus is Associated with the Immunoglobulin G N-Glycome through Putative Proinflammatory Mechanisms in an Australian Population. Li X, et al. • Omics: a Journal of Integrative Biology Next-Generation (Glycomic) Biomarkers for Cardiometabolic Health: A Community-Based Study of Immunoglobulin G N-Glycans in a Chinese Han Population. Wang H, et al. • Omics: a Journal of Integrative Biology Altered N-glycosylation profiles as potential biomarkers and drug targets in diabetes. Rudman N, et al. • FEBS Letters Glycomics for Type 2 Diabetes Biomarker Discovery: Promise of Immunoglobulin G Subclass-Specific Fragment Crystallizable N-glycosylation in the Uyghur Population. Liu J, et al. • Omics: a Journal of Integrative Biology N-Glycan Analysis by Ultra-Performance Liquid Chromatography and Capillary Gel Electrophoresis with Fluorescent Labeling Hanic M, et al. • Current protocols in protein science Intense Physical Exercise Induces an Anti-inflammatory Change in IgG N-Glycosylation Profile Marko Tijardović, et al. • Frontiers in Physiology Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans. Russell AC, et al. • Immunobiology Comprehensive N-glycosylation analysis of immunoglobulin G from dried blood spots Simunovic J, et al. • Glycobiology Molecular Pathways Mediating Immunosuppression in Response to Prolonged Intensive Physical Training, Low-Energy Availability, and Intensive Weight Loss. Sarin HV, et al. • Frontiers in Immunology Breaking the Glyco-Code of HIV Persistence and Immunopathogenesis. Colomb F, et al. • Current HIV/AIDS reports IgG Glycans as a Biomarker of Biological Age M. Vilaj et al. • Springer Decreased Complexity of Serum N-glycan Structures Associates with Successful Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection Tanya M. Monaghan et al. • Gastroenterology
2018
The association between subclass-specific IgG Fc N-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations. Liu JN, et al. • Journal of Human Hypertension Genome-wide association study on immunoglobulin G glycosylation patterns. Wahl A, et al. • Frontiers in Immunology Immunoglobulin G glycosylation in aging and diseases. Gudelj I, et al. • Cell Immunol IgG glycosylation and DNA methylation are interconnected with smoking. Wahl A, et al. • Biochimica et Biophysica Acta The changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia. Liu D, et al. • Journal of Translational Medicine The sweet spot for biologics: recent advances in characterization of biotherapeutic glycoproteins. O'Flaherty R, et al. • Expert Review of Proteomics Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation Zaghlool SB, et al. • Human Molecular Genetics Glycosylation profile of immunoglobulin G is cross-sectionally associated with cardiovascular disease risk score and subclinical atherosclerosis in two independent cohorts. Menni C, et al. • Circulation Research Glycosylation of immunoglobulin G associates with clinical features of inflammatory bowel diseases. Simurina M, et al. • Gastroenterology Promoter methylation of the MGAT3 and BACH2 genes correlates with the composition of the immunoglobulin G glycome in inflammatory bowel disease. Klasic M, et al. • Clinical Epigenetics Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up. Gudelj I, et al. • Biochimica et Biophysica Acta N-glycosylation patterns of plasma proteins and immunoglobulin G in chronic obstructive pulmonary disease. Pavic T, et al. • Journal of Translational Medicine Frontline Science: Plasma and immunoglobulin G galactosylation associate with HIV persistence during antiretroviral therapy. Vadrevu SK, et al. • Journal of Leukocyte Biology
2017
Estrogens regulate glycosylation of IgG in women and men. Ercan A, et al. • JJCI Insight,The Journal of Clinical Investigation Ubiquitous importance of protein glycosylation. Kristic J, et al. • Methods in Molecular Biology Multivariate discovery and replication of five novel loci associated with immunoglobulin G N-glycosylation. Shen X, et al. • Nature Communications IgG glycan patterns are associated with type 2 diabetes in independent European populations. Lemmers RFH, et al. • Biochimica et Biophysica Acta Connecting genetic risk to disease end points through the human blood plasma proteome. Suhre K, et al. • Nature Communications Immunoglobulin G N-glycans as potential postgenomic biomarkers for hypertension in the Kazakh population. Gao Q, et al. • Omics: a Journal of Integrative Biology The N-glycosylation of immunoglobulin G as a novel biomarker of Parkinson's disease. Russell AC, et al. • Glycobiology Effects of statins on the immunoglobulin G glycome. Keser T, et al. • Biochimica et Biophysica Acta Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway. Benedetti E, et al. • Nature Communications
2016
The association between glycosylation of immunoglobulin G and hypertension: A multiple ethnic cross-sectional study. Wang Y, et al. • Medicine High-throughput analysis of immunoglobulin G glycosylation. Trbojevic-Akmacic I, et al. • Expert Review of Proteomics IgG glycome in colorectal cancer. Vuckovic F, et al. • Reports Precision medicine that transcends genomics: Glycans as integrators of genes and environment. Lauc G • Biochimica et Biophysica Acta Effects of allergic diseases and age on the composition of serum IgG glycome in children. Pezer M, et al. • Scientific Reports The association between low back pain and composition of IgG glycome. Freidin MB, et al. • Scientific Reports Glycosylation of plasma IgG in colorectal cancer prognosis. Theodoratou E, et al. • Clinical Cancer Research Mechanisms of disease: The human N-glycome. Lauc G, et al. • Biochimica et Biophysica Acta Exploring the molecular basis of age-related disease comorbidities using a multi-omics graphical model. Zierer J, et al. • Scientific Reports Profiling IgG N-glycans as potential biomarker of chronological and biological ages: A community-based study in a Han Chinese population. Yu X, et al. • Medicine
2015
Glycosylation profile of IgG in moderate kidney dysfunction. Barrios C, et al. • JASN, Journal of the American Society of Nephrology Association of systemic lupus erythematosus with decreased immunosuppressive potential of the IgG glycome. Vuckovic F, et al. • Arthritis & Rheumatology Estimation of human age using N-glycan profiles from bloodstains. Gudelj I, et al. • International Journal of Legal Medicine Inflammatory bowel disease associates with proinflammatory potential of the immunoglobulin G glycome. Trbojevic Akmacic I, et al. • Inflammatory Bowel Diseases Integration of 'omics' data in aging research: from biomarkers to systems biology. Zierer J, et al. • Aging Cell
2014
Glycans - the third revolution in evolution. Lauc G, et al. • Frontiers in Genetics Glycans are a novel biomarker of chronological and biological ages. Kristic J, et al. • The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences Changes in IgG and total plasma protein glycomes in acute systemic inflammation. Novokmet M, et al. • Scientific Reports Comparative performance of four methods for high-throughput glycosylation analysis of immunoglobulin G in genetic and epidemiological research. Huffman JE, et al. • Molecular & Cellular Proteomics Epigenetic regulation of glycosylation is the quantum mechanics of biology. Lauc G, et al. • Biochimica et Biophysica Acta The role of glycosylation in IBD. Theodoratou E, et al. • Nature Reviews Gastroenterology & Hepatology The association between galactosylation of immunoglobulin G and body mass index. Nikolac Perkovic M, et al. • Progress in Neuro-Psychopharmacology & Biological Psychiatry
2013
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. Lauc G, et al. • PLOS Genetics Glycosylation of immunoglobulin G: Role of genetic and epigenetic influences. Menni C, et al. • PLOS ONE Glycomics meets genomics, epigenomics and other high throughput omics for system biology studies. Zoldos V, et al. • Current Opinion in Chemical Biology Genomics and epigenomics of the human glycome. Zoldos V, et al. • Glycoconjugate Journal High-throughput IgG Fc N-glycosylation profiling by mass spectrometry of glycopeptides Pucic Bakovic M, et al. • Journal of Proteome Research Omics technologies and the study of human ageing. Valdes AM, et al. • Nature Reviews Genetics
2012
Changes in plasma and IgG N-glycome during childhood and adolescence. Pucic M, et al. • Glycobiology The future of glycoscience. Lauc G. • Biochimica et Biophysica Acta Alternative glycosylation modulates function of IgG and other proteins - implications on evolution and disease. Gornik O, et al. • Biochimica et Biophysica Acta
2011
Evolutional and clinical implications of the epigenetic regulation of protein glycosylation. Horvat T, et al. • Clinical Epigenetics Polymorphisms in B3GAT1, SLC9A9 and MGAT5 are associated with variation within the human plasma N-glycome of 3533 European adults. Huffman JE, et al. • Human Molecular Genetics Screening novel biomarkers for metabolic syndrome by profiling human plasma N-glycans in Chinese Han and Croatian populations. Lu JP, et al. • Journal of Proteome Research High throughput isolation and glycosylation analysis of IgG-variability and heritability of the IgG glycome in three isolated human populations. Pucic M, et al. • Molecular & Cellular Proteomics High throughput plasma N-glycome profiling using multiplexed labelling and UPLC with fluorescence detection. Knezevic A, et al. • The Analyst
2010
Epigenetic regulation of protein glycosylation. Zoldos V, et al. • Biomolecular Concepts Complex genetic regulation of protein glycosylation. Lauc G, et al. • Molecular BioSystems Genomics meets glycomics-the first GWAS study of human N-glycome identifies HNF1α as a master regulator of plasma protein fucosylation. Lauc G, et al. • PLOS Genetics Protein glycosylation-an evolutionary crossroad between genes and environment. Lauc G, et al. • Molecular BioSystems Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans. Knezevic A, et al. • Glycobiology
2009
Stability of N-glycan profiles in human plasma. Gornik O, et al. • Glycobiology Variability, heritability and environmental determinants of human plasma N-glycome. Knezevic A, et al. • Journal of Proteome Research Epigenetic regulation of glycosylation could be a mechanism used by complex organisms to compete with microbes on an evolutionary scale. Lauc G, et al. • Medical Hypotheses
1999