Our research team
2024
Variability of human Alpha-1-acid glycoprotein N-glycome in a Caucasian population Frano Vučković, Mislav Novokmet,Frano Vučković, Gordan Lauc, at al. • GLYCOBIOLOGY Functional Signature of LRP4 Antibodies in Myasthenia Gravis Omar Chuquisana, at al. • Neurology Journals Alterations in plasma protein N-glycosylation after caloric restriction and bariatric surgery Štambuk T, et al. • Surgery for Obesity and Related Diseases Anastrozole and Tamoxifen Impact on IgG Glycome Composition Dynamics in Luminal A and Luminal B Breast Cancers Rapčan B, et al. • Antibodies N-Glycosylation Profiles of Immunoglobulin G and Future Cardiovascular Events Hoshi RA, et al. • Circulation Research MMP3 single-nucleotide polymorphisms are associated with noncontact ACL injuries in competing high-level athletes Šimunić-Briški N, et al. • Journal of Orthopaedic Research The use of a systems approach to increase NAD+ in human participants Henderson JD, et al. • npj Aging Influence of Desialylation on the Drug Binding Affinity of Human Alpha-1-Acid Glycoprotein Assessed by Microscale Thermophoresis Šeba T, et al. • Pharmaceutics
2023
Key Publication Reversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction Horvath S, et al. • GeroscienceKey Publication IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy Shkunnikova S, et al. • Biotechnology AdvancesKey Publication Regular moderate physical exercise decreases Glycan Age index of biological age and reduces inflammatory potential of Immunoglobulin G Šimunić-Briški N, et al. • Glycoconjugate JournalKey Publication Mapping of the gene network that regulates glycan clock of ageing Azra Frkatović-Hodžić A, et al. • AgingKey Publication Can we suppress chronic systemic inflammation and postpone age-related diseases by targeting the IgG glycome? Lauc G, et al. • Expert Opinion on Therapeutic Targets Higher MRI lesion load in multiple sclerosis is related to the N-glycosylation changes of cerebrospinal fluid immunoglobulin G Turčić A, et al. • Multiple Sclerosis and Related Disorders IgG N-Glycosylation Is Altered in Coronary Artery Disease Radovani B, et al. • Biomolecules Periodic Changes in the N-Glycosylation of Immunoglobulin G During the Menstrual Cycle Jurić J, et al. • Engineering Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels Murray A, et al. • eBioMedicine The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder Tudor L, et al. • International Journal of Molecular Sciences Storage stability and HILIC-UHPLC-FLR analysis of immunoglobulin G N-glycome from saliva Radovani B, et al. • Analytical and Bioanalytical Chemistry Total serum N-glycans associate with response to immune checkpoint inhibition therapy and survival in patients with advanced melanoma Visconti A, et al. • BMC Cancer High-throughput immunoaffinity enrichment and N-glycan analysis of human plasma haptoglobin Šimunović J., et al. • Biotechnology and Bioengineering Comparative analysis of transferrin and IgG N-glycosylation in two human populations Trbojević-Akmačić I, et al. • Communications Biology The N-Glycosylation of Total Plasma Proteins and IgG in Atrial Fibrillation Branimir Plavša B, et al. • Biomolecules Anti-TNF Biologicals Enhance the Anti-Inflammatory Properties of IgG N-Glycome in Crohn's Disease Hanić M, et al. • Biomolecules Plasma protein N-glycome composition associates with postprandial lipaemic response Louca P, et al. • BMC Medicine IgG N-glycans are associated with prevalent and incident complications of type 2 diabetes Memarian E, et al. • Diabetes/Metabolism Research and Reviews Human complement component C3 N-glycome changes in type 1 diabetes complications Šoić D, et al. • Frontiers in Endocrinology IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy Sofia Shkunnikova et al. • ScienceDirect Not-So-Sweet Dreams: Plasma and IgG N-Glycome in the Severe Form of the Obstructive Sleep Apnea Doris Plećaš et al. • Biomolecules Human-specific features and developmental dynamics of the brain N-glycome Thomas S Klarić et al. • NCBI PubMed
2022
Key Publication Immunoglobulin G glycome composition in transition from premenopause to postmenopause Gordan Lauc et al. • iScienceKey Publication IgG N-glycome changes during the course of severe COVID-19: An observational study Tea Petrović, et al. • The LancetKey Publication A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk Azra Frkatović et al. • Aging Immunoglobulin G N-Glycosylation Signatures in Incident Type 2 Diabetes and Cardiovascular Disease Gordan Lauc et al. • Diabetes Journals The dynamic brain N-glycome Thomas S. Klarić & Gordan Lauc • Springer High-throughput human complement C3 N-glycoprofiling identifies markers of early onset type 1 diabetes mellitus in children Dinko Šoić et al • MCP Distinct Longitudinal Changes in Immunoglobulin G N-Glycosylation Associate with Therapy Response in Chronic Inflammatory Diseases Jerko Štambuk et al • MDPI, International Journal of Molecular Sciences Glycosylation Profile of Immunoglobulin G and Incident Cardiovascular Events: Secondary Analysis of Two Randomized Clinical Trials Gordan Lauc et al. • AHA Journals Blood plasma/IgG N-glycome biosignatures associated with major depressive disorder symptom severity and the antidepressant response Gordan Lauc et al. • Nature N-Glycosylation and Inflammation; the Not-So-Sweet Relation Ivan Gudelj and Barbara Radovani • Frontiers Developments and perspectives in high-throughput protein glycomics: enabling the analysis of thousands of samples Gordan Lauc, PhD et al. • Oxford Academic Effects of low-calorie and different weight-maintenance diets on IgG glycome composition Helena Deriš et al. • Frontiers Immunoglobulin G glycans – Biomarkers and molecular effectors of aging Jasminka Krištić et al • ScienceDirect High-Throughput Glycomic Methods Gordan Lauc et al. • Chemical Reviews Heritability of the glycan clock of biological age Anika Mijakovac et al. • Frontiers Fucosylated AGP glycopeptides as biomarkers of HNF1A-Maturity onset diabetes of the young Marko Tijardovic et al. • Elsevier Baseline IgG-Fc N-glycosylation profile is associated with long-term outcome in a cohort of early inflammatory arthritis patients Sénard et al • BMC Arthritis Research & Therapy Altered IgG glycosylation at COVID-19 diagnosis predicts disease severity Gordan Lauc, et al. • European Journal of Immunology A Transient Expression System with Stably Integrated CRISPR-dCas9 Fusions for Regulation of Genes Involved in Immunoglobulin G Glycosylation Gordan Lauc, et al. • The CRISPR Journal Differences in Immunoglobulin G Glycosylation Between Influenza and COVID-19 Patients Marina Kljaković-Gašpić Batinjan et al. • Sience Direct
2021
Key Publication Investigation of the causal relationships between human IgG N-glycosylation and twelve common diseases associated with changes in the IgG N-glycome Olga O Zaytseva, et al. • Oxford Academic Key Publication Plasma N-glycome shows continuous deterioration as the diagnosis of insulin resistance approaches Ana Cvetko, et al. • BMJ JournalsKey Publication Extensive weight loss reduces glycan age by altering IgG N-glycosylation Valentina L Greto, et al. • International Journal of ObesityKey Publication Systems Glycobiology: Immunoglobulin G Glycans as Biomarkers and Functional Effectors in Aging and Diseases Marija Martinić Kavur, Gordan Lauc and Marija Pezer • ScienceDirect Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India Tanya M. Monaghan, et al. • Microorganisms Effects of Estradiol on Immunoglobulin G Glycosylation: Mapping of the Downstream Signaling Mechanism Anika Mijakovac, et al. • Frontiers in Immunology Targeting B cells in the pre-phase of systemic autoimmunity globally interferes with autoimmune pathology Anja Werner, et al. • Cell A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection Tanya M. Monaghan, et al. • Cells N-glycosylation of immunoglobulin G predicts incident hypertension Gordan Lauc et al. • Journal of hypertension Immunoglobulin G glycome composition in transition from pre-menopause to menopause Domagoj Kifer, et al. • MedRxiv
2020
Key Publication Effects of estradiol on biological age measured using the glycan age index Julija Jurić, et al. • AgeingKey Publication Global variability of the human IgG glycome. Jerko Štambuk, et al. • Ageing Composition of the immunoglobulin G glycome associates with the severity of COVID-19 Tea Petrović, et al. • Glycobiology N-glycans as functional effectors of genetic and epigenetic disease risk Tamara Štambuk et al. • Science direct Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases Tiphaine C. Martin, et al. • Mollecular & Cellular proteomics Plasma N-Glycans as Emerging Biomarkers of Cardiometabolic Risk: A Prospective Investigation in the EPIC-Potsdam Cohort Study Clemens Wittenbecher, et al. • Diabetes Care Minimal B Cell Extrinsic IgG Glycan Modifications of Pro- and Anti-Inflammatory IgG Preparations in vivo Anja Schaffert, et al. • Frontiers in Immunology Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases Lucija Klarić, et al. • Science Advances Searching for glycomic biomarkers for predicting resilience and vulnerability in a rat model of posttraumatic stress disorder Csilla Lea Fazekasab, et al. • The International Journal on the Biology of Stress Biomarkers of biological age as predictors of COVID-19 disease severity Gordan Lauc, David Sinclair • Ageing
2019
Key Publication Supplementation with the Sialic Acid Precursor N-acetyl-D-Mannosamine Breaks the Link Between Obesity and Hypertension. Jun P, et al. • Circulation Translational glycobiology: from bench to bedside. Axford J, et al. • Journal of Royal Society of Medicine IgG Glycans as a Biomarker of Biological Age M. Vilaj et al. • Springer Inflammatory bowel disease - glycomics perspective. Wang H, et al. • Biochimica et Biophysica Acta Type 2 Diabetes Mellitus is Associated with the Immunoglobulin G N-Glycome through Putative Proinflammatory Mechanisms in an Australian Population. Li X, et al. • Omics: a Journal of Integrative Biology Decreased Complexity of Serum N-glycan Structures Associates with Successful Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection Tanya M. Monaghan et al. • Gastroenterology Next-Generation (Glycomic) Biomarkers for Cardiometabolic Health: A Community-Based Study of Immunoglobulin G N-Glycans in a Chinese Han Population. Wang H, et al. • Omics: a Journal of Integrative Biology Altered N-glycosylation profiles as potential biomarkers and drug targets in diabetes. Rudman N, et al. • FEBS Letters Glycomics for Type 2 Diabetes Biomarker Discovery: Promise of Immunoglobulin G Subclass-Specific Fragment Crystallizable N-glycosylation in the Uyghur Population. Liu J, et al. • Omics: a Journal of Integrative Biology N-Glycan Analysis by Ultra-Performance Liquid Chromatography and Capillary Gel Electrophoresis with Fluorescent Labeling Hanic M, et al. • Current protocols in protein science Intense Physical Exercise Induces an Anti-inflammatory Change in IgG N-Glycosylation Profile Marko Tijardović, et al. • Frontiers in Physiology Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans. Russell AC, et al. • Immunobiology Comprehensive N-glycosylation analysis of immunoglobulin G from dried blood spots Simunovic J, et al. • Glycobiology Molecular Pathways Mediating Immunosuppression in Response to Prolonged Intensive Physical Training, Low-Energy Availability, and Intensive Weight Loss. Sarin HV, et al. • Frontiers in Immunology Breaking the Glyco-Code of HIV Persistence and Immunopathogenesis. Colomb F, et al. • Current HIV/AIDS reports Association of the IgG N-glycome with the course of kidney function in type 2 diabetes Sunny S Singh, et al. • BMJ Journals
2018
Key Publication Genome-wide association study on immunoglobulin G glycosylation patterns. Wahl A, et al. • Frontiers in ImmunologyKey Publication Immunoglobulin G glycosylation in aging and diseases. Gudelj I, et al. • Cell Immunol The association between subclass-specific IgG Fc N-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations. Liu JN, et al. • Journal of Human Hypertension The sweet spot for biologics: recent advances in characterization of biotherapeutic glycoproteins. O'Flaherty R, et al. • Expert Review of Proteomics IgG glycosylation and DNA methylation are interconnected with smoking. Wahl A, et al. • Biochimica et Biophysica Acta Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation Zaghlool SB, et al. • Human Molecular Genetics The changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia. Liu D, et al. • Journal of Translational Medicine Glycosylation profile of immunoglobulin G is cross-sectionally associated with cardiovascular disease risk score and subclinical atherosclerosis in two independent cohorts. Menni C, et al. • Circulation Research Glycosylation of immunoglobulin G associates with clinical features of inflammatory bowel diseases. Simurina M, et al. • Gastroenterology Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up. Gudelj I, et al. • Biochimica et Biophysica Acta Promoter methylation of the MGAT3 and BACH2 genes correlates with the composition of the immunoglobulin G glycome in inflammatory bowel disease. Klasic M, et al. • Clinical Epigenetics N-glycosylation patterns of plasma proteins and immunoglobulin G in chronic obstructive pulmonary disease. Pavic T, et al. • Journal of Translational Medicine Frontline Science: Plasma and immunoglobulin G galactosylation associate with HIV persistence during antiretroviral therapy. Vadrevu SK, et al. • Journal of Leukocyte Biology
2017
Key Publication Estrogens regulate glycosylation of IgG in women and men. Ercan A, et al. • JJCI Insight,The Journal of Clinical InvestigationKey Publication IgG glycan patterns are associated with type 2 diabetes in independent European populations. Lemmers RFH, et al. • Biochimica et Biophysica ActaKey Publication Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway. Benedetti E, et al. • Nature Communications Ubiquitous importance of protein glycosylation. Kristic J, et al. • Methods in Molecular Biology Multivariate discovery and replication of five novel loci associated with immunoglobulin G N-glycosylation. Shen X, et al. • Nature Communications Connecting genetic risk to disease end points through the human blood plasma proteome. Suhre K, et al. • Nature Communications Immunoglobulin G N-glycans as potential postgenomic biomarkers for hypertension in the Kazakh population. Gao Q, et al. • Omics: a Journal of Integrative Biology The N-glycosylation of immunoglobulin G as a novel biomarker of Parkinson's disease. Russell AC, et al. • Glycobiology Effects of statins on the immunoglobulin G glycome. Keser T, et al. • Biochimica et Biophysica Acta
2016
Key Publication High-throughput analysis of immunoglobulin G glycosylation. Trbojevic-Akmacic I, et al. • Expert Review of ProteomicsKey Publication Mechanisms of disease: The human N-glycome. Lauc G, et al. • Biochimica et Biophysica Acta The association between glycosylation of immunoglobulin G and hypertension: A multiple ethnic cross-sectional study. Wang Y, et al. • Medicine IgG glycome in colorectal cancer. Vuckovic F, et al. • Reports Precision medicine that transcends genomics: Glycans as integrators of genes and environment. Lauc G • Biochimica et Biophysica Acta Effects of allergic diseases and age on the composition of serum IgG glycome in children. Pezer M, et al. • Scientific Reports The association between low back pain and composition of IgG glycome. Freidin MB, et al. • Scientific Reports Glycosylation of plasma IgG in colorectal cancer prognosis. Theodoratou E, et al. • Clinical Cancer Research Exploring the molecular basis of age-related disease comorbidities using a multi-omics graphical model. Zierer J, et al. • Scientific Reports Profiling IgG N-glycans as potential biomarker of chronological and biological ages: A community-based study in a Han Chinese population. Yu X, et al. • Medicine
2015
Key Publication Estimation of human age using N-glycan profiles from bloodstains. Gudelj I, et al. • International Journal of Legal Medicine Glycosylation profile of IgG in moderate kidney dysfunction. Barrios C, et al. • JASN, Journal of the American Society of Nephrology Association of systemic lupus erythematosus with decreased immunosuppressive potential of the IgG glycome. Vuckovic F, et al. • Arthritis & Rheumatology Inflammatory bowel disease associates with proinflammatory potential of the immunoglobulin G glycome. Trbojevic Akmacic I, et al. • Inflammatory Bowel Diseases Integration of 'omics' data in aging research: from biomarkers to systems biology. Zierer J, et al. • Aging Cell
2014
Key Publication Glycans - the third revolution in evolution. Lauc G, et al. • Frontiers in GeneticsKey Publication Glycans are a novel biomarker of chronological and biological ages. Kristic J, et al. • The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences Comparative performance of four methods for high-throughput glycosylation analysis of immunoglobulin G in genetic and epidemiological research. Huffman JE, et al. • Molecular & Cellular Proteomics Changes in IgG and total plasma protein glycomes in acute systemic inflammation. Novokmet M, et al. • Scientific Reports Epigenetic regulation of glycosylation is the quantum mechanics of biology. Lauc G, et al. • Biochimica et Biophysica Acta The role of glycosylation in IBD. Theodoratou E, et al. • Nature Reviews Gastroenterology & Hepatology The association between galactosylation of immunoglobulin G and body mass index. Nikolac Perkovic M, et al. • Progress in Neuro-Psychopharmacology & Biological Psychiatry
2013
Key Publication Glycosylation of immunoglobulin G: Role of genetic and epigenetic influences. Menni C, et al. • PLOS ONEKey Publication Omics technologies and the study of human ageing. Valdes AM, et al. • Nature Reviews Genetics Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. Lauc G, et al. • PLOS Genetics Glycomics meets genomics, epigenomics and other high throughput omics for system biology studies. Zoldos V, et al. • Current Opinion in Chemical Biology Genomics and epigenomics of the human glycome. Zoldos V, et al. • Glycoconjugate Journal High-throughput IgG Fc N-glycosylation profiling by mass spectrometry of glycopeptides Pucic Bakovic M, et al. • Journal of Proteome Research
2012
Changes in plasma and IgG N-glycome during childhood and adolescence. Pucic M, et al. • Glycobiology The future of glycoscience. Lauc G. • Biochimica et Biophysica Acta Alternative glycosylation modulates function of IgG and other proteins - implications on evolution and disease. Gornik O, et al. • Biochimica et Biophysica Acta
2011
Evolutional and clinical implications of the epigenetic regulation of protein glycosylation. Horvat T, et al. • Clinical Epigenetics Polymorphisms in B3GAT1, SLC9A9 and MGAT5 are associated with variation within the human plasma N-glycome of 3533 European adults. Huffman JE, et al. • Human Molecular Genetics Screening novel biomarkers for metabolic syndrome by profiling human plasma N-glycans in Chinese Han and Croatian populations. Lu JP, et al. • Journal of Proteome Research High throughput isolation and glycosylation analysis of IgG-variability and heritability of the IgG glycome in three isolated human populations. Pucic M, et al. • Molecular & Cellular Proteomics High throughput plasma N-glycome profiling using multiplexed labelling and UPLC with fluorescence detection. Knezevic A, et al. • The Analyst
2010
Key Publication Protein glycosylation-an evolutionary crossroad between genes and environment. Lauc G, et al. • Molecular BioSystems Epigenetic regulation of protein glycosylation. Zoldos V, et al. • Biomolecular Concepts Genomics meets glycomics-the first GWAS study of human N-glycome identifies HNF1α as a master regulator of plasma protein fucosylation. Lauc G, et al. • PLOS Genetics Complex genetic regulation of protein glycosylation. Lauc G, et al. • Molecular BioSystems Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans. Knezevic A, et al. • Glycobiology
2009
Stability of N-glycan profiles in human plasma. Gornik O, et al. • Glycobiology Variability, heritability and environmental determinants of human plasma N-glycome. Knezevic A, et al. • Journal of Proteome Research Epigenetic regulation of glycosylation could be a mechanism used by complex organisms to compete with microbes on an evolutionary scale. Lauc G, et al. • Medical Hypotheses
1999