GlycanAge Blog: Glycoscience · Page 4

Glycans in Drug Discovery - HIV Glycopeptide Antigens

Glycoproteins found at the surface of several viruses are called viral envelope glycoproteins and they are great targets for virus neutralisation. Synthetic glycopeptides that mimic natural HIV envelope glycoproteins have been considered as anti-HIV therapy. Viral envelope glycoproteins, such as gp120 in HIV-1, have g…

Published:
April 2, 2020 Reading time:
5 minutes

The Importance of IgG Glycosylation in Drug Development

Antibodies can be used preventatively as vaccines, but also as post-diagnosis treatment for many human diseases including cancer and immunologic illnesses. Both the production and market of therapeutic antibodies have undergone exponential growth in the past few years, and this trend is not expected to stop anytime so…

Published:
April 1, 2020 Reading time:
5 minutes

The Sars-Cov-2 Spike Protein Is Densely Glycosylated

The spike protein is a trimeric protein on the surface of the SARS-CoV-2. This protein gives the whole viral family a crown-like appearance by forming spikes on their surface, hence their name – corona (Latin for crown). The spike protein mediates receptor recognition and membrane fusion during host cell infection. Du…

Published:
March 26, 2020 Reading time:
5 minutes

Glycans in Nanotechnology

Nanotechnology is technology, science and engineering conducted at the nanoscale, which is about 1 to 100 nanometers, to create, manipulate, and characterize structures on those scales. As it is shown, glycans are applicable biomarkers for medical diagnostic. It is known that material properties are changed on nanosca…

Published:
March 26, 2020 Reading time:
5 minutes

Have Glycans Finally Found a Place in Medicine?

Complex sugar molecules called glycans are an essential component to life as we know it since they are estimated to be the most abundant class of organic molecules on Earth. They are present in all domains of life, taking different shapes and sizes – from a single monosaccharide to the complex polysaccharides containi…

Published:
March 26, 2020 Reading time:
5 minutes

Intestinal Microbiota and Glycosylation

The human colon is extensively colonized with bacteria, fungi, and viruses. This colony of commensal, symbiotic and pathogenic microorganisms remains stable throughout the years but can change in some diseases (e.g., inflammatory bowel disease, HIV infection) and as a result of different environmental factors (e.g., d…

Published:
March 25, 2020 Reading time:
5 minutes

Glycomic Diversity of Homogenous Cell Populations

Published:
March 24, 2020

A Targeted Approach to Determining the Human Glycome

Published:
March 24, 2020

Glycomes of Cancer and Autoimmune Diseases

Published:
March 24, 2020 Reading time:
5 minutes

Glycans as Biomarkers and Functional Effectors in Diabetes and Cardiovascular Diseases

Published:
March 24, 2020 Reading time:
5 minutes

The Human Glycome Project

Published:
March 24, 2020

Genes Regulating Variation of Protein N-Glycosylation in Human Populations

Published:
March 23, 2020