GlycanAge publications

GlycanAge is based on research performed on over 200,000 people.

These findings identified that glycans change 7-10 years before the disease is first diagnosed. Glycans also respond to lifestyle interventions within a short timeframe, providing valuable insights.

If you’re interested in including glycans in your research, check out our Research page to see how we can collaborate.

You can see all of our publications in chronological order below.

2024

Variability of human Alpha-1-acid glycoprotein N-glycome in a Caucasian population

Frano Vučković, Mislav Novokmet,Frano Vučković, Gordan Lauc, at al. - GLYCOBIOLOGY

https://academic.oup.com/glycob/article-abstract/34/6/cwae031/7642698?redirectedFrom=fulltext

Functional Signature of LRP4 Antibodies in Myasthenia Gravis

Omar Chuquisana, at al. - Neurology Journals

https://www.neurology.org/doi/full/10.1212/NXI.0000000000200220

Alterations in plasma protein N-glycosylation after caloric restriction and bariatric surgery

Štambuk T, et al. - Surgery for Obesity and Related Diseases

https://www.soard.org/article/S1550-7289(24)00032-7/abstract

Anastrozole and Tamoxifen Impact on IgG Glycome Composition Dynamics in Luminal A and Luminal B Breast Cancers

Rapčan B, et al. - Antibodies

https://www.mdpi.com/2073-4468/13/1/9

N-Glycosylation Profiles of Immunoglobulin G and Future Cardiovascular Events

Hoshi RA, et al. - Circulation Research

https://www.ahajournals.org/doi/abs/10.1161/CIRCRESAHA.123.323623

MMP3 single-nucleotide polymorphisms are associated with noncontact ACL injuries in competing high-level athletes

Šimunić-Briški N, et al. - Journal of Orthopaedic Research

https://pubmed.ncbi.nlm.nih.gov/37442641/

The use of a systems approach to increase NAD+ in human participants

Henderson JD, et al. - npj Aging

https://www.nature.com/articles/s41514-023-00134-0

Influence of Desialylation on the Drug Binding Affinity of Human Alpha-1-Acid Glycoprotein Assessed by Microscale Thermophoresis

Šeba T, et al. - Pharmaceutics

https://www.mdpi.com/1999-4923/16/2/230

2023

Reversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction

Horvath S, et al. - Geroscience

https://link.springer.com/article/10.1007/s11357-023-00980-6

Higher MRI lesion load in multiple sclerosis is related to the N-glycosylation changes of cerebrospinal fluid immunoglobulin G

Turčić A, et al. - Multiple Sclerosis and Related Disorders

https://www.msard-journal.com/article/S2211-0348(23)00422-4/abstract

IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy

Shkunnikova S, et al. - Biotechnology Advances

https://www.sciencedirect.com/science/article/pii/S0734975023000769?via%3Dihub

IgG N-Glycosylation Is Altered in Coronary Artery Disease

Radovani B, et al. - Biomolecules

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953309/

Periodic Changes in the N-Glycosylation of Immunoglobulin G During the Menstrual Cycle

Jurić J, et al. - Engineering

https://www.sciencedirect.com/science/article/pii/S2095809923002436

Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels

Murray A, et al. - eBioMedicine

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435767/

The Association of the Polymorphisms in the FUT8-Related Locus with the Plasma Glycosylation in Post-Traumatic Stress Disorder

Tudor L, et al. - International Journal of Molecular Sciences

https://www.mdpi.com/1422-0067/24/6/5706

Storage stability and HILIC-UHPLC-FLR analysis of immunoglobulin G N-glycome from saliva

Radovani B, et al. - Analytical and Bioanalytical Chemistry

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101819/

Total serum N-glycans associate with response to immune checkpoint inhibition therapy and survival in patients with advanced melanoma

Visconti A, et al. - BMC Cancer

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938582/

High-throughput immunoaffinity enrichment and N-glycan analysis of human plasma haptoglobin

Šimunović J., et al. - Biotechnology and Bioengineering

https://pubmed.ncbi.nlm.nih.gov/36324280/

Comparative analysis of transferrin and IgG N-glycosylation in two human populations

Trbojević-Akmačić I, et al. - Communications Biology

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10036557/

The N-Glycosylation of Total Plasma Proteins and IgG in Atrial Fibrillation

Branimir Plavša B, et al. - Biomolecules

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135591/

Anti-TNF Biologicals Enhance the Anti-Inflammatory Properties of IgG N-Glycome in Crohn's Disease

Hanić M, et al. - Biomolecules

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10295852/

Regular moderate physical exercise decreases Glycan Age index of biological age and reduces inflammatory potential of Immunoglobulin G

Šimunić-Briški N, et al. - Glycoconjugate Journal

https://link.springer.com/article/10.1007/s10719-023-10144-5

Plasma protein N-glycome composition associates with postprandial lipaemic response

Louca P, et al. - BMC Medicine

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318725/

IgG N-glycans are associated with prevalent and incident complications of type 2 diabetes

Memarian E, et al. - Diabetes/Metabolism Research and Reviews

https://onlinelibrary.wiley.com/doi/10.1002/dmrr.3685

Mapping of the gene network that regulates glycan clock of ageing

Azra Frkatović-Hodžić A, et al. - Aging

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10781487/

Can we suppress chronic systemic inflammation and postpone age-related diseases by targeting the IgG glycome?

Lauc G, et al. - Expert Opinion on Therapeutic Targets

https://www.tandfonline.com/doi/full/10.1080/14728222.2023.2277218

Human complement component C3 N-glycome changes in type 1 diabetes complications

Šoić D, et al. - Frontiers in Endocrinology

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244649/

IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy

Sofia Shkunnikova et al. - ScienceDirect

https://www.sciencedirect.com/science/article/pii/S0734975023000769

Not-So-Sweet Dreams: Plasma and IgG N-Glycome in the Severe Form of the Obstructive Sleep Apnea

Doris Plećaš et al. - Biomolecules

https://www.mdpi.com/2218-273X/13/6/880

Human-specific features and developmental dynamics of the brain N-glycome

Thomas S Klarić et al. - NCBI PubMed

https://pubmed.ncbi.nlm.nih.gov/36711977/

2022

Immunoglobulin G N-Glycosylation Signatures in Incident Type 2 Diabetes and Cardiovascular Disease

Gordan Lauc et al. - Diabetes Journals

https://diabetesjournals.org/care/article/45/11/2729/147697/Immunoglobulin-G-N-Glycosylation-Signatures-in

The dynamic brain N-glycome

Thomas S. Klarić & Gordan Lauc - Springer

https://link.springer.com/article/10.1007/s10719-022-10055-x

High-throughput human complement C3 N-glycoprofiling identifies markers of early onset type 1 diabetes mellitus in children

Dinko Šoić et al - MCP

https://www.mcponline.org/article/S1535-9476(22)00215-8/fulltext

Distinct Longitudinal Changes in Immunoglobulin G N-Glycosylation Associate with Therapy Response in Chronic Inflammatory Diseases

Jerko Štambuk et al - MDPI, International Journal of Molecular Sciences

https://www.mdpi.com/1422-0067/23/15/8473

Glycosylation Profile of Immunoglobulin G and Incident Cardiovascular Events: Secondary Analysis of Two Randomized Clinical Trials

Gordan Lauc et al. - AHA Journals

https://www.ahajournals.org/doi/abs/10.1161/circ.146.suppl_1.11057

Blood plasma/IgG N-glycome biosignatures associated with major depressive disorder symptom severity and the antidepressant response

Gordan Lauc et al. - Nature

https://www.nature.com/articles/s41598-017-17500-0

N-Glycosylation and Inflammation; the Not-So-Sweet Relation

Ivan Gudelj and Barbara Radovani - Frontiers

https://www.frontiersin.org/articles/10.3389/fimmu.2022.893365/full

Developments and perspectives in high-throughput protein glycomics: enabling the analysis of thousands of samples

Gordan Lauc, PhD et al. - Oxford Academic

https://academic.oup.com/glycob/article/32/8/651/6572164

Immunoglobulin G glycome composition in transition from premenopause to postmenopause

Gordan Lauc et al. - iScience

https://www.cell.com/iscience/pdf/S2589-0042(22)00167-5.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004222001675%3Fshowall%3Dtrue

Effects of low-calorie and different weight-maintenance diets on IgG glycome composition

Helena Deriš et al. - Frontiers

https://www.frontiersin.org/articles/10.3389/fimmu.2022.995186/abstract

Immunoglobulin G glycans – Biomarkers and molecular effectors of aging

Jasminka Krištić et al - ScienceDirect

https://www.sciencedirect.com/science/article/abs/pii/S0009898122012578

High-Throughput Glycomic Methods

Gordan Lauc et al. - Chemical Reviews

https://pubs.acs.org/doi/10.1021/acs.chemrev.1c01031

Heritability of the glycan clock of biological age

Anika Mijakovac et al. - Frontiers

https://www.frontiersin.org/articles/10.3389/fcell.2022.982609/abstract

Fucosylated AGP glycopeptides as biomarkers of HNF1A-Maturity onset diabetes of the young

Marko Tijardovic et al. - Elsevier

https://www.diabetesresearchclinicalpractice.com/action/showPdf?pii=S0168-8227%2822%2900038-9

Baseline IgG-Fc N-glycosylation profile is associated with long-term outcome in a cohort of early inflammatory arthritis patients

Sénard et al - BMC Arthritis Research & Therapy

https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-022-02897-5

Altered IgG glycosylation at COVID-19 diagnosis predicts disease severity

Gordan Lauc, et al. - European Journal of Immunology

https://onlinelibrary.wiley.com/doi/10.1002/eji.202149491

IgG N-glycome changes during the course of severe COVID-19: An observational study

Tea Petrović, et al. - The Lancet

https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00282-1/fulltext

A Transient Expression System with Stably Integrated CRISPR-dCas9 Fusions for Regulation of Genes Involved in Immunoglobulin G Glycosylation

Gordan Lauc, et al. - The CRISPR Journal

https://www.liebertpub.com/doi/epub/10.1089/crispr.2021.0089

A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk

Azra Frkatović et al. - Aging

https://www.aging-us.com/article/203847/text

Differences in Immunoglobulin G Glycosylation Between Influenza and COVID-19 Patients

Marina Kljaković-Gašpić Batinjan et al. - Sience Direct

https://www.sciencedirect.com/science/article/pii/S2095809922006312

2021

Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India

Tanya M. Monaghan, et al. - Microorganisms

https://www.mdpi.com/2076-2607/9/7/1485

Investigation of the causal relationships between human IgG N-glycosylation and twelve common diseases associated with changes in the IgG N-glycome

Olga O Zaytseva, et al. - Oxford Academic

https://academic.oup.com/hmg/advance-article-abstract/doi/10.1093/hmg/ddab335/6428118?fbclid=IwAR3-VPO6KBeiEcIedUDJXtyLBDezfo7jwL7HM2APOtMj9izx901YOhM6p1Y

Effects of Estradiol on Immunoglobulin G Glycosylation: Mapping of the Downstream Signaling Mechanism

Anika Mijakovac, et al. - Frontiers in Immunology

https://www.frontiersin.org/articles/10.3389/fimmu.2021.680227/full

Targeting B cells in the pre-phase of systemic autoimmunity globally interferes with autoimmune pathology

Anja Werner, et al. - Cell

https://www.cell.com/iscience/fulltext/S2589-0042(21)01044-0#%20

Plasma N-glycome shows continuous deterioration as the diagnosis of insulin resistance approaches

Ana Cvetko, et al. - BMJ Journals

https://drc.bmj.com/content/9/1/e002263.info

Extensive weight loss reduces glycan age by altering IgG N-glycosylation

Valentina L Greto, et al. - International Journal of Obesity

https://www.nature.com/articles/s41366-021-00816-3.epdf?sharing_token=NHFBegLn0sO-YJ-1a9x3ttRgN0jAjWel9jnR3ZoTv0NODh881xrqt-RyR9vH4f4bcJyK9xkbke9NyB5E97YF7AcOicx1_8mlvl97vmAu1cJg_-uBLa2_pkSubBtpRYfJ_VNwpMWjRkWlZmYwzp7D7sSLfUchh_094Ch8ip26tiY%3D

A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection

Tanya M. Monaghan, et al. - Cells

https://www.mdpi.com/2073-4409/10/11/3234

Systems Glycobiology: Immunoglobulin G Glycans as Biomarkers and Functional Effectors in Aging and Diseases

Marija Martinić Kavur, Gordan Lauc and Marija Pezer - ScienceDirect

https://firebasestorage.googleapis.com/v0/b/genos-glyco.appspot.com/o/Systems%20Glycobiology.pdf?alt=media&token=c29421fa-d9fc-40f4-a34c-b15cb6ab9d0b

N-glycosylation of immunoglobulin G predicts incident hypertension

Gordan Lauc et al. - Journal of hypertension

https://journals.lww.com/jhypertension/Fulltext/2021/12000/N_glycosylation_of_immunoglobulin_G_predicts.24.aspx

Immunoglobulin G glycome composition in transition from pre-menopause to menopause

Domagoj Kifer, et al. - MedRxiv

https://www.medrxiv.org/content/10.1101/2021.04.10.21255252v1

2020

Composition of the immunoglobulin G glycome associates with the severity of COVID-19

Tea Petrović, et al. - Glycobiology

https://academic.oup.com/glycob/advance-article/doi/10.1093/glycob/cwaa102/5970509

N-glycans as functional effectors of genetic and epigenetic disease risk

Tamara Štambuk et al. - Science direct

https://www.sciencedirect.com/science/article/abs/pii/S009829972030056X?via%3Dihub

Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases

Tiphaine C. Martin, et al. - Mollecular & Cellular proteomics

https://www.mcponline.org/article/S1535-9476(20)35003-9/fulltext

Plasma N-Glycans as Emerging Biomarkers of Cardiometabolic Risk: A Prospective Investigation in the EPIC-Potsdam Cohort Study

Clemens Wittenbecher, et al. - Diabetes Care

https://care.diabetesjournals.org/content/early/2020/01/06/dc19-1507

Minimal B Cell Extrinsic IgG Glycan Modifications of Pro- and Anti-Inflammatory IgG Preparations in vivo

Anja Schaffert, et al. - Frontiers in Immunology

https://www.frontiersin.org/articles/10.3389/fimmu.2019.03024/full

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

Lucija Klarić, et al. - Science Advances

https://advances.sciencemag.org/content/6/8/eaax0301

Searching for glycomic biomarkers for predicting resilience and vulnerability in a rat model of posttraumatic stress disorder

Csilla Lea Fazekasab, et al. - The International Journal on the Biology of Stress

https://www.tandfonline.com/doi/abs/10.1080/10253890.2020.1795121?journalCode=ists20

Effects of estradiol on biological age measured using the glycan age index

Julija Jurić, et al. - Ageing

https://www.aging-us.com/article/104060

Biomarkers of biological age as predictors of COVID-19 disease severity

Gordan Lauc, David Sinclair - Ageing

https://www.aging-us.com/article/103052

Global variability of the human IgG glycome.

Jerko Štambuk, et al. - Ageing

https://www.aging-us.com/article/103884/text

2019

Translational glycobiology: from bench to bedside.

Axford J, et al. - Journal of Royal Society of Medicine

https://www.ncbi.nlm.nih.gov/pubmed/31526214

Supplementation with the Sialic Acid Precursor N-acetyl-D-Mannosamine Breaks the Link Between Obesity and Hypertension.

Jun P, et al. - Circulation

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.043490

IgG Glycans as a Biomarker of Biological Age

M. Vilaj et al. - Springer

https://link.springer.com/chapter/10.1007/978-3-030-24970-0_7

Inflammatory bowel disease - glycomics perspective.

Wang H, et al. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/31276732

Type 2 Diabetes Mellitus is Associated with the Immunoglobulin G N-Glycome through Putative Proinflammatory Mechanisms in an Australian Population.

Li X, et al. - Omics: a Journal of Integrative Biology

https://www.ncbi.nlm.nih.gov/pubmed/31526239

Decreased Complexity of Serum N-glycan Structures Associates with Successful Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection

Tanya M. Monaghan et al. - Gastroenterology

https://www.gastrojournal.org/article/S0016-5085(19)41259-6/fulltext?referrer=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F

Next-Generation (Glycomic) Biomarkers for Cardiometabolic Health: A Community-Based Study of Immunoglobulin G N-Glycans in a Chinese Han Population.

Wang H, et al. - Omics: a Journal of Integrative Biology

https://www.ncbi.nlm.nih.gov/pubmed/31313980

Altered N-glycosylation profiles as potential biomarkers and drug targets in diabetes.

Rudman N, et al. - FEBS Letters

https://www.ncbi.nlm.nih.gov/pubmed/31215021

Glycomics for Type 2 Diabetes Biomarker Discovery: Promise of Immunoglobulin G Subclass-Specific Fragment Crystallizable N-glycosylation in the Uyghur Population.

Liu J, et al. - Omics: a Journal of Integrative Biology

https://www.ncbi.nlm.nih.gov/pubmed/31393219

N-Glycan Analysis by Ultra-Performance Liquid Chromatography and Capillary Gel Electrophoresis with Fluorescent Labeling

Hanic M, et al. - Current protocols in protein science

https://www.ncbi.nlm.nih.gov/pubmed/31517449

Intense Physical Exercise Induces an Anti-inflammatory Change in IgG N-Glycosylation Profile

Marko Tijardović, et al. - Frontiers in Physiology

https://www.frontiersin.org/articles/10.3389/fphys.2019.01522/full

Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans.

Russell AC, et al. - Immunobiology

https://www.ncbi.nlm.nih.gov/pubmed/30446335

Comprehensive N-glycosylation analysis of immunoglobulin G from dried blood spots

Simunovic J, et al. - Glycobiology

https://www.ncbi.nlm.nih.gov/pubmed/31410450

Molecular Pathways Mediating Immunosuppression in Response to Prolonged Intensive Physical Training, Low-Energy Availability, and Intensive Weight Loss.

Sarin HV, et al. - Frontiers in Immunology

https://www.ncbi.nlm.nih.gov/pubmed/31134054

Breaking the Glyco-Code of HIV Persistence and Immunopathogenesis.

Colomb F, et al. - Current HIV/AIDS reports

https://www.ncbi.nlm.nih.gov/pubmed/30707400

Association of the IgG N-glycome with the course of kidney function in type 2 diabetes

Sunny S Singh, et al. - BMJ Journals

https://drc.bmj.com/content/8/1/e001026.long

2018

The association between subclass-specific IgG Fc N-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations.

Liu JN, et al. - Journal of Human Hypertension

https://www.ncbi.nlm.nih.gov/pubmed/29867134

Genome-wide association study on immunoglobulin G glycosylation patterns.

Wahl A, et al. - Frontiers in Immunology

https://www.ncbi.nlm.nih.gov/pubmed/29535710

Immunoglobulin G glycosylation in aging and diseases.

Gudelj I, et al. - Cell Immunol

https://www.ncbi.nlm.nih.gov/pubmed/30107893

The sweet spot for biologics: recent advances in characterization of biotherapeutic glycoproteins.

O'Flaherty R, et al. - Expert Review of Proteomics

https://www.ncbi.nlm.nih.gov/pubmed/29130774

IgG glycosylation and DNA methylation are interconnected with smoking.

Wahl A, et al. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/29055820

Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation

Zaghlool SB, et al. - Human Molecular Genetics

https://www.ncbi.nlm.nih.gov/pubmed/29325019

The changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia.

Liu D, et al. - Journal of Translational Medicine

https://www.ncbi.nlm.nih.gov/pubmed/30157878

Glycosylation profile of immunoglobulin G is cross-sectionally associated with cardiovascular disease risk score and subclinical atherosclerosis in two independent cohorts.

Menni C, et al. - Circulation Research

https://www.ncbi.nlm.nih.gov/pubmed/29535164

Glycosylation of immunoglobulin G associates with clinical features of inflammatory bowel diseases.

Simurina M, et al. - Gastroenterology

https://www.ncbi.nlm.nih.gov/pubmed/29309774

Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up.

Gudelj I, et al. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/29572115

Promoter methylation of the MGAT3 and BACH2 genes correlates with the composition of the immunoglobulin G glycome in inflammatory bowel disease.

Klasic M, et al. - Clinical Epigenetics

https://www.ncbi.nlm.nih.gov/pubmed/29991969

N-glycosylation patterns of plasma proteins and immunoglobulin G in chronic obstructive pulmonary disease.

Pavic T, et al. - Journal of Translational Medicine

https://www.ncbi.nlm.nih.gov/pubmed/30463578

Frontline Science: Plasma and immunoglobulin G galactosylation associate with HIV persistence during antiretroviral therapy.

Vadrevu SK, et al. - Journal of Leukocyte Biology

https://www.ncbi.nlm.nih.gov/pubmed/29633346

2017

Estrogens regulate glycosylation of IgG in women and men.

Ercan A, et al. - JJCI Insight,The Journal of Clinical Investigation

https://www.ncbi.nlm.nih.gov/pubmed/28239652

Ubiquitous importance of protein glycosylation.

Kristic J, et al. - Methods in Molecular Biology

https://www.ncbi.nlm.nih.gov/pubmed/27743354

Multivariate discovery and replication of five novel loci associated with immunoglobulin G N-glycosylation.

Shen X, et al. - Nature Communications

https://www.ncbi.nlm.nih.gov/pubmed/28878392

IgG glycan patterns are associated with type 2 diabetes in independent European populations.

Lemmers RFH, et al. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/28668296

Connecting genetic risk to disease end points through the human blood plasma proteome.

Suhre K, et al. - Nature Communications

https://www.ncbi.nlm.nih.gov/pubmed/28240269

Immunoglobulin G N-glycans as potential postgenomic biomarkers for hypertension in the Kazakh population.

Gao Q, et al. - Omics: a Journal of Integrative Biology

https://www.ncbi.nlm.nih.gov/pubmed/28692416

The N-glycosylation of immunoglobulin G as a novel biomarker of Parkinson's disease.

Russell AC, et al. - Glycobiology

https://www.ncbi.nlm.nih.gov/pubmed/28334832

Effects of statins on the immunoglobulin G glycome.

Keser T, et al. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/28263871

Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway.

Benedetti E, et al. - Nature Communications

https://www.ncbi.nlm.nih.gov/pubmed/29133956

2016

The association between glycosylation of immunoglobulin G and hypertension: A multiple ethnic cross-sectional study.

Wang Y, et al. - Medicine

https://www.ncbi.nlm.nih.gov/pubmed/27124023

High-throughput analysis of immunoglobulin G glycosylation.

Trbojevic-Akmacic I, et al. - Expert Review of Proteomics

https://www.ncbi.nlm.nih.gov/pubmed/27043342

IgG glycome in colorectal cancer.

Vuckovic F, et al. - Reports

https://www.ncbi.nlm.nih.gov/pubmed/26831718

Precision medicine that transcends genomics: Glycans as integrators of genes and environment.

Lauc G - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/27155579

Effects of allergic diseases and age on the composition of serum IgG glycome in children.

Pezer M, et al. - Scientific Reports

https://www.ncbi.nlm.nih.gov/pubmed/27616597

The association between low back pain and composition of IgG glycome.

Freidin MB, et al. - Scientific Reports

https://www.ncbi.nlm.nih.gov/pubmed/27229623

Glycosylation of plasma IgG in colorectal cancer prognosis.

Theodoratou E, et al. - Clinical Cancer Research

https://www.ncbi.nlm.nih.gov/pubmed/27302279

Mechanisms of disease: The human N-glycome.

Lauc G, et al. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/26500099

Exploring the molecular basis of age-related disease comorbidities using a multi-omics graphical model.

Zierer J, et al. - Scientific Reports

https://www.ncbi.nlm.nih.gov/pubmed/27886242

Profiling IgG N-glycans as potential biomarker of chronological and biological ages: A community-based study in a Han Chinese population.

Yu X, et al. - Medicine

https://www.ncbi.nlm.nih.gov/pubmed/27428197

2015

Glycosylation profile of IgG in moderate kidney dysfunction.

Barrios C, et al. - JASN, Journal of the American Society of Nephrology

https://www.ncbi.nlm.nih.gov/pubmed/26185202

Association of systemic lupus erythematosus with decreased immunosuppressive potential of the IgG glycome.

Vuckovic F, et al. - Arthritis & Rheumatology

https://www.ncbi.nlm.nih.gov/pubmed/26200652

Estimation of human age using N-glycan profiles from bloodstains.

Gudelj I, et al. - International Journal of Legal Medicine

https://www.ncbi.nlm.nih.gov/pubmed/25787342

Inflammatory bowel disease associates with proinflammatory potential of the immunoglobulin G glycome.

Trbojevic Akmacic I, et al. - Inflammatory Bowel Diseases

https://www.ncbi.nlm.nih.gov/pubmed/25895110

Integration of 'omics' data in aging research: from biomarkers to systems biology.

Zierer J, et al. - Aging Cell

https://www.ncbi.nlm.nih.gov/pubmed/26331998

2014

Glycans - the third revolution in evolution.

Lauc G, et al. - Frontiers in Genetics

https://www.ncbi.nlm.nih.gov/pubmed/24904645

Glycans are a novel biomarker of chronological and biological ages.

Kristic J, et al. - The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

https://www.ncbi.nlm.nih.gov/pubmed/24325898

Comparative performance of four methods for high-throughput glycosylation analysis of immunoglobulin G in genetic and epidemiological research.

Huffman JE, et al. - Molecular & Cellular Proteomics

https://www.ncbi.nlm.nih.gov/pubmed/24719452

Changes in IgG and total plasma protein glycomes in acute systemic inflammation.

Novokmet M, et al. - Scientific Reports

https://www.ncbi.nlm.nih.gov/pubmed/24614541

Epigenetic regulation of glycosylation is the quantum mechanics of biology.

Lauc G, et al. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/23999089

The role of glycosylation in IBD.

Theodoratou E, et al. - Nature Reviews Gastroenterology & Hepatology

https://www.ncbi.nlm.nih.gov/pubmed/24912389

The association between galactosylation of immunoglobulin G and body mass index.

Nikolac Perkovic M, et al. - Progress in Neuro-Psychopharmacology & Biological Psychiatry

https://www.ncbi.nlm.nih.gov/pubmed/24012618

2013

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

Lauc G, et al. - PLOS Genetics

https://www.ncbi.nlm.nih.gov/pubmed/23382691

Glycosylation of immunoglobulin G: Role of genetic and epigenetic influences.

Menni C, et al. - PLOS ONE

https://www.ncbi.nlm.nih.gov/pubmed/24324808

Glycomics meets genomics, epigenomics and other high throughput omics for system biology studies.

Zoldos V, et al. - Current Opinion in Chemical Biology

https://www.ncbi.nlm.nih.gov/pubmed/23287290

Genomics and epigenomics of the human glycome.

Zoldos V, et al. - Glycoconjugate Journal

https://www.ncbi.nlm.nih.gov/pubmed/22648057

High-throughput IgG Fc N-glycosylation profiling by mass spectrometry of glycopeptides

Pucic Bakovic M, et al. - Journal of Proteome Research

https://www.ncbi.nlm.nih.gov/pubmed/23298168

Omics technologies and the study of human ageing.

Valdes AM, et al. - Nature Reviews Genetics

https://www.ncbi.nlm.nih.gov/pubmed/23938363

2012

Changes in plasma and IgG N-glycome during childhood and adolescence.

Pucic M, et al. - Glycobiology

https://pubmed.ncbi.nlm.nih.gov/22426998/

The future of glycoscience.

Lauc G. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/22727214

Alternative glycosylation modulates function of IgG and other proteins - implications on evolution and disease.

Gornik O, et al. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/22183029

2011

Evolutional and clinical implications of the epigenetic regulation of protein glycosylation.

Horvat T, et al. - Clinical Epigenetics

https://www.ncbi.nlm.nih.gov/pubmed/22704355

Polymorphisms in B3GAT1, SLC9A9 and MGAT5 are associated with variation within the human plasma N-glycome of 3533 European adults.

Huffman JE, et al. - Human Molecular Genetics

https://www.ncbi.nlm.nih.gov/pubmed/21908519

Screening novel biomarkers for metabolic syndrome by profiling human plasma N-glycans in Chinese Han and Croatian populations.

Lu JP, et al. - Journal of Proteome Research

https://www.ncbi.nlm.nih.gov/pubmed/21939225

High throughput isolation and glycosylation analysis of IgG-variability and heritability of the IgG glycome in three isolated human populations.

Pucic M, et al. - Molecular & Cellular Proteomics

https://www.ncbi.nlm.nih.gov/pubmed/21653738

High throughput plasma N-glycome profiling using multiplexed labelling and UPLC with fluorescence detection.

Knezevic A, et al. - The Analyst

https://www.ncbi.nlm.nih.gov/pubmed/21956149

2010

Epigenetic regulation of protein glycosylation.

Zoldos V, et al. - Biomolecular Concepts

https://www.ncbi.nlm.nih.gov/pubmed/25962001

Genomics meets glycomics-the first GWAS study of human N-glycome identifies HNF1α as a master regulator of plasma protein fucosylation.

Lauc G, et al. - PLOS Genetics

https://www.ncbi.nlm.nih.gov/pubmed/21203500

Complex genetic regulation of protein glycosylation.

Lauc G, et al. - Molecular BioSystems

https://www.ncbi.nlm.nih.gov/pubmed/20094651

Protein glycosylation-an evolutionary crossroad between genes and environment.

Lauc G, et al. - Molecular BioSystems

https://www.ncbi.nlm.nih.gov/pubmed/20957246

Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans.

Knezevic A, et al. - Glycobiology

https://www.ncbi.nlm.nih.gov/pubmed/20356825

2009

Stability of N-glycan profiles in human plasma.

Gornik O, et al. - Glycobiology

https://www.ncbi.nlm.nih.gov/pubmed/19726492

Variability, heritability and environmental determinants of human plasma N-glycome.

Knezevic A, et al. - Journal of Proteome Research

https://www.ncbi.nlm.nih.gov/pubmed/19035662

Epigenetic regulation of glycosylation could be a mechanism used by complex organisms to compete with microbes on an evolutionary scale.

Lauc G, et al. - Medical Hypotheses

https://www.ncbi.nlm.nih.gov/pubmed/19560282

2008

Glycosylation of serum proteins in inflammatory diseases.

Gornik O, et al. - Disease Markers

https://www.ncbi.nlm.nih.gov/pubmed/19126970

2006

Sweet secret of the multicellular life.

Lauc G. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/16431025

2004

Stress causes tissue-specific changes in the sialyltransferase activity.

Dabelic S, et al. - Zeitschrift fur Naturforschung C, A Journal of Biosciences

https://www.ncbi.nlm.nih.gov/pubmed/15241940

1999

Purification and MALDI-MS characterization of stressin, a stress-associated glycoprotein.

Lauc G, et al. - Biological Chemistry

https://www.ncbi.nlm.nih.gov/pubmed/10355630

Fucosylation of IgG heavy chains is increased in rheumatoid arthritis.

Gornik I, et al. - Clinical Biochemistry

https://www.ncbi.nlm.nih.gov/pubmed/10638942

1998

Fucosylation and galactosylation of IgG heavy chains differ between acute and remission phases of juvenile chronic arthritis.

Flögel M, et al. - Clinical Chemistry and Laboratory Medicine

https://www.ncbi.nlm.nih.gov/pubmed/9594046

1996

Changes of glycoprotein patterns in sera of humans under stress.

Barisic K, et al. - European Journal of Clinical Chemistry and Clinical Biochemistry: Journal of the Forum of European Clinical Chemistry Societies

https://www.ncbi.nlm.nih.gov/pubmed/8833640

1991

Human brain gangliosides in development, aging and disease

Gordan Lauc et al. - Int. J. Dev. Biol.

http://www.ijdb.ehu.es/web/paper.php?doi=1814411