What Are Glycans - GlycanAge

The science
of GlycanAge


Your GlycanAge is the most accurate guide to your biological age. Our innovative test has been developed by researching over 80,000 people worldwide.


What are glycans?

Glycans are one of four building blocks of life (alongside proteins, nucleic acids and lipids). They are complex sugars that are involved in almost every process in our body.

Every person in the world has a particular glycosylation pattern - a bit like DNA. But unlike DNA, we have the power to affect our glycans by improving our health and lifestyle.

Many external factors that could affect our health leave a mark on our glycan pattern. Through researching more than 80,000 people worldwide, we’re able to accurately analyse these patterns. The result is the most accurate biological age - your GlycanAge.


Why is biological age important?

Age. We all know it’s just a number. What if you had a better number? One that gave you a more accurate idea of your health. Your biological age - your GlycanAge.

This single number could empower you to stay healthier, and younger, for longer. Because unlike normal age, your lifestyle choices can affect your GlycanAge. Using pioneering science, you can now discover your GlycanAge, and turn back the hands of time.


The GlycanAge method

First we take a small blood sample. It’s quick, safe and virtually pain-free.

Using a process called liquid chromatography we analyse your glycans. Your sample is sent to the world’s leading high-throughput glycoanalytical laboratory.  Our experts will analyse your immunoglobulin G glycan pattern. 4 weeks after your sample has been received in the lab, you’ll get your GlycanAge results. You’ll be able to make informed decisions about your health and lifestyle. Because with knowledge comes control.

Publications


GlycanAge is based on research performed on over 80,000 individuals. Here are the selected scientific publications in peer-reviewed journals describing the discoveries that lead to the GlycanAge test development and have enabled its continuous refinement.


Translational glycobiology: from bench to bedside. Axford J, et al. Journal of Royal Society of Medicine, 2019.
Inflammatory bowel disease - glycomics perspective. Wang H, et al. Biochimica et Biophysica Acta, 2019.
Breaking the Glyco-Code of HIV Persistence and Immunopathogenesis. Colomb F, et al. Current HIV/AIDS reports, 2019.
Immunoglobulin G glycosylation in aging and diseases. Gudelj I, et al. Cell Immunol, 2018.
IgG glycosylation and DNA methylation are interconnected with smoking. Wahl A, et al. Biochimica et Biophysica Acta, 2018.
The changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia. Liu D, et al. Journal of Translational Medicine, 2018.
Estrogens regulate glycosylation of IgG in women and men. Ercan A, et al. JJCI Insight,The Journal of Clinical Investigation, 2017.
Ubiquitous importance of protein glycosylation. Kristic J, et al. Methods in Molecular Biology, 2017.
Effects of statins on the immunoglobulin G glycome. Keser T, et al. Biochimica et Biophysica Acta, 2017.
Glycosylation profile of IgG in moderate kidney dysfunction. Barrios C, et al. JASN, Journal of the American Society of Nephrology, 2016.
High-throughput analysis of immunoglobulin G glycosylation. Trbojevic-Akmacic I, et al. Expert Review of Proteomics, 2016.
IgG glycome in colorectal cancer. Vuckovic F, et al. Reports, 2016.
The association between low back pain and composition of IgG glycome. Freidin MB, et al. Scientific Reports, 2016.
Glycosylation of plasma IgG in colorectal cancer prognosis. Theodoratou E, et al. Clinical Cancer Research, 2016.
Mechanisms of disease: The human N-glycome. Lauc G, et al. Biochimica et Biophysica Acta, 2016.
Estimation of human age using N-glycan profiles from bloodstains. Gudelj I, et al. International Journal of Legal Medicine, 2015.
Glycans - the third revolution in evolution. Lauc G, et al. Frontiers in Genetics, 2014.
Glycans are a novel biomarker of chronological and biological ages. Kristic J, et al. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 2014.
Epigenetic regulation of glycosylation is the quantum mechanics of biology. Lauc G, et al. Biochimica et Biophysica Acta, 2014.
The role of glycosylation in IBD. Theodoratou E, et al. Nature Reviews Gastroenterology & Hepatology, 2014.
The association between galactosylation of immunoglobulin G and body mass index. Nikolac Perkovic M, et al. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2014.
Genomics and epigenomics of the human glycome. Zoldos V, et al. Glycoconjugate Journal, 2013.
High-throughput IgG Fc N-glycosylation profiling by mass spectrometry of glycopeptides. Pucic Bakovic M, et al. Journal of Proteome Research, 2013.
Omics technologies and the study of human ageing. Valdes AM, et al. Nature Reviews Genetics, 2013.
The future of glycoscience. Lauc G. Biochimica et Biophysica Acta, 2012.
Epigenetic regulation of protein glycosylation. Zoldos V, et al. Biomolecular Concepts, 2010.
Complex genetic regulation of protein glycosylation. Lauc G, et al. Molecular BioSystems, 2010.
Stability of N-glycan profiles in human plasma. Gornik O, et al. Glycobiology, 2009.
Variability, heritability and environmental determinants of human plasma N-glycome. Knezevic A, et al. Journal of Proteome Research, 2009.
Glycosylation of serum proteins in inflammatory diseases. Gornik O, et al. Disease Markers, 2008.
Sweet secret of the multicellular life. Lauc G. Biochimica et Biophysica Acta, 2006.
Stress causes tissue-specific changes in the sialyltransferase activity. Dabelic S, et al. Zeitschrift fur Naturforschung C, A Journal of Biosciences, 2004.
Fucosylation of IgG heavy chains is increased in rheumatoid arthritis. Gornik I, et al. Clinical Biochemistry, 1999.
Changes of glycoprotein patterns in sera of humans under stress. Barisic K, et al. European Journal of Clinical Chemistry and Clinical Biochemistry: Journal of the Forum of European Clinical Chemistry Societies, 1996.