2022

Immunoglobulin G glycome composition in transition from premenopause to postmenopause

Helena Deriš, Domagoj Kifer, Ana Cindrić, Tea Petrović, Ana Cvetko, Irena Trbojević- Akmačić, Ivana Kolčić, Ozren Polašek, Louise Newson, Tim Spector, Cristina Menni, Gordan Lauc - iScience

https://www.cell.com/iscience/pdf/S2589-0042(22)00167-5.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004222001675%3Fshowall%3Dtrue

Altered IgG glycosylation at COVID-19 diagnosis predicts disease severity

Gordan Lauc, Manuel M. Vicente,Inês Alves,Joana Gaifem,Cláudia S. Rodrigues,Ângela Fernandes,Ana M. Dias,Jerko Štambuk,Tea Petrović,Pedro Oliveira,Frederico Ferreira-da-Silva,Adriana Soares,Nair Seixas,Tiago Teixeira,Luis Malheiro,Miguel M. Abreu,Rui Sarmento e Castro,Salomé S. Pinho - European Journal of Immunology

https://onlinelibrary.wiley.com/doi/10.1002/eji.202149491

A Transient Expression System with Stably Integrated CRISPR-dCas9 Fusions for Regulation of Genes Involved in Immunoglobulin G Glycosylation

Anika Mijakovac, Karlo Miškec, Jasminka Krištić, Vedrana Vičić Bočkor, Vanja Tadić, Maria Bošković, Gordan Lauc, Vlatka Zoldoš, and Aleksandar Vojta - The CRISPR Journal

https://www.liebertpub.com/doi/epub/10.1089/crispr.2021.0089

A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk

Azra Frkatović et al. - Aging

https://www.aging-us.com/article/203847/text

2021

Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India

Tanya M. Monaghan, et al. - Microorganisms

https://www.mdpi.com/2076-2607/9/7/1485

Key Publication

Investigation of the causal relationships between human IgG N-glycosylation and twelve common diseases associated with changes in the IgG N-glycome

Olga O Zaytseva, et al. - Oxford Academic

https://academic.oup.com/hmg/advance-article-abstract/doi/10.1093/hmg/ddab335/6428118?fbclid=IwAR3-VPO6KBeiEcIedUDJXtyLBDezfo7jwL7HM2APOtMj9izx901YOhM6p1Y

Effects of Estradiol on Immunoglobulin G Glycosylation: Mapping of the Downstream Signaling Mechanism

Anika Mijakovac, et al. - Frontiers in Immunology

https://www.frontiersin.org/articles/10.3389/fimmu.2021.680227/full

Targeting B cells in the pre-phase of systemic autoimmunity globally interferes with autoimmune pathology

Anja Werner, et al. - Cell

https://www.cell.com/iscience/fulltext/S2589-0042(21)01044-0#%20

Key Publication

Plasma N-glycome shows continuous deterioration as the diagnosis of insulin resistance approaches

Ana Cvetko, et al. - BMJ Journals

https://drc.bmj.com/content/9/1/e002263.info

Key Publication

Extensive weight loss reduces glycan age by altering IgG N-glycosylation

Valentina L Greto, et al. - International Journal of Obesity

https://www.nature.com/articles/s41366-021-00816-3.epdf?sharing_token=NHFBegLn0sO-YJ-1a9x3ttRgN0jAjWel9jnR3ZoTv0NODh881xrqt-RyR9vH4f4bcJyK9xkbke9NyB5E97YF7AcOicx1_8mlvl97vmAu1cJg_-uBLa2_pkSubBtpRYfJ_VNwpMWjRkWlZmYwzp7D7sSLfUchh_094Ch8ip26tiY%3D

A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection

Tanya M. Monaghan, et al. - Cells

https://www.mdpi.com/2073-4409/10/11/3234

Key Publication

N-glycosylation of immunoglobulin G predicts incident hypertension

Domagoj Kifer, et al. - Journal of Hypertension

https://journals.lww.com/jhypertension/Abstract/9000/N_glycosylation_of_immunoglobulin_G_predicts.96614.aspx

Key Publication

Systems Glycobiology: Immunoglobulin G Glycans as Biomarkers and Functional Effectors in Aging and Diseases

Marija Martinić Kavur, Gordan Lauc and Marija Pezer - ScienceDirect

https://firebasestorage.googleapis.com/v0/b/genos-glyco.appspot.com/o/Systems%20Glycobiology.pdf?alt=media&token=c29421fa-d9fc-40f4-a34c-b15cb6ab9d0b

Immunoglobulin G glycome composition in transition from pre-menopause to menopause

Domagoj Kifer, et al. - MedRxiv

https://www.medrxiv.org/content/10.1101/2021.04.10.21255252v1

2020

Composition of the immunoglobulin G glycome associates with the severity of COVID-19

Tea Petrović, et al. - Glycobiology

https://academic.oup.com/glycob/advance-article/doi/10.1093/glycob/cwaa102/5970509

Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases

Tiphaine C. Martin, et al. - Mollecular & Cellular proteomics

https://www.mcponline.org/article/S1535-9476(20)35003-9/fulltext

Minimal B Cell Extrinsic IgG Glycan Modifications of Pro- and Anti-Inflammatory IgG Preparations in vivo

Anja Schaffert, et al. - Frontiers in Immunology

https://www.frontiersin.org/articles/10.3389/fimmu.2019.03024/full

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

Lucija Klarić, et al. - Science Advances

https://advances.sciencemag.org/content/6/8/eaax0301

Searching for glycomic biomarkers for predicting resilience and vulnerability in a rat model of posttraumatic stress disorder

Csilla Lea Fazekasab, et al. - The International Journal on the Biology of Stress

https://www.tandfonline.com/doi/abs/10.1080/10253890.2020.1795121?journalCode=ists20

Key Publication

Effects of estradiol on biological age measured using the glycan age index

Julija Jurić, et al. - Ageing

https://www.aging-us.com/article/104060

Biomarkers of biological age as predictors of COVID-19 disease severity

Gordan Lauc, David Sinclair - Ageing

https://www.aging-us.com/article/103052/text

Key Publication

Plasma n-glycans as emerging biomarkers of cardiomatabolic risk: a prospective investigation in the epic-potsdam cohort study

C Wittenbecher, et al. - Diabetes Care

https://care.diabetesjournals.org/content/early/2020/01/06/dc19-1507

Key Publication

Global variability of the human IgG glycome

Jerko Štambuk, et al. - Ageing

https://www.aging-us.com/article/103884/text

2019

Glycomics for type 2 diabetes biomarker discovery: promise of immunoglobulin g subclass-specific fragment crystallizable n-glycosylation in the Uyghur population.

Liu J, et al. - Omics: a Journal of Integrative Biology

https://www.ncbi.nlm.nih.gov/pubmed/31393219

N-glycan analysis by ultra-performance liquid chromatography and capillary gel electrophoresis with fluorescent labelling.

Hanic M, et al. - Current protocols in protein science

https://www.ncbi.nlm.nih.gov/pubmed/31517449

Supplementation with the sialic acid precursor n-acetyl-d-mannosamine breaks the link between obesity and hypertension.

Jun Peng, et al. - Circulation

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.043490

Association of the IgG N-glycome with the course of kidney function in type 2 diabetes

Sunny S Singh, et al. - BMJ Journals

https://drc.bmj.com/content/8/1/e001026.long

Inflammatory bowel disease - glycomics perspective.

Wang H, et al. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/31276732

Translational glycobiology: from bench to bedside.

Axford J, et al. - Journal of Royal Society of Medicine

https://www.ncbi.nlm.nih.gov/pubmed/31526214

Comprehensive n-glycosylation analysis of immunoglobulin g from dried blood spots

Simunovic J, et al. - Glycobiology

https://www.ncbi.nlm.nih.gov/pubmed/31410450

Molecular pathways mediating immunosuppression in response to prolonged intensive physical training, low-energy availability, and intensive weight loss.

Sarin HV, et al. - Frontiers in Immunology

https://www.ncbi.nlm.nih.gov/pubmed/31134054

Altered n-glycosylation profiles as potential biomarkers and drug targets in diabetes.

Rudman N, et al. - FEBS Letters

https://www.ncbi.nlm.nih.gov/pubmed/31215021

Type 2 diabetes mellitus is associated with the immunoglobulin g n-glycome through putative proinflammatory mechanisms in an Australian population.

Li X, et al. - Omics: a Journal of Integrative Biology

https://www.ncbi.nlm.nih.gov/pubmed/31526239

Intense physical exercise indicates an anti-inflammatory change in igg n-glycosylation profile

Marko Tijardović, et al. - Frontiers in Physiology

https://www.frontiersin.org/articles/10.3389/fphys.2019.01522/full

Next-generation (glycomic) biomarkers for cardiometabolic health: a community-based study of immunoglobulin g n-glycans in a Chinese Han population.

Wang H, et al. - Omics: a Journal of Integrative Biology

https://www.ncbi.nlm.nih.gov/pubmed/31313980

Breaking the glyco-code of HIV persistence and immunopathogenesis.

Colomb F, et al. - Current HIV/AIDS reports

https://www.ncbi.nlm.nih.gov/pubmed/30707400

2018

N-glycosylation patterns of plasma proteins and immunoglobulin g in chronic obstructive pulmonary disease.

Pavic T, et al. - Journal of Translational Medicine

https://www.ncbi.nlm.nih.gov/pubmed/30463578

Low galactosylation of igg associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up.

Gudelj I, et al. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/29572115

The changes of immunoglobulin G n-glycosylation in blood lipids and dyslipidaemia.

Liu D, et al. - Journal of Translational Medicine

https://www.ncbi.nlm.nih.gov/pubmed/30157878

Frontline Science: plasma and immunoglobulin g galactosylation associate with HIV persistence during antiretroviral therapy.

Vadrevu SK, et al. - Journal of Leukocyte Biology

https://www.ncbi.nlm.nih.gov/pubmed/29633346

Deep molecular phenotypes link complex disorders and physiological insult to CPG methylation.

Zaghlool SB, et al. - Human Molecular Genetics

https://www.ncbi.nlm.nih.gov/pubmed/29325019

Network inference from glycoproteomics data reveals new reactions in the igg glycosylation pathway.

Benedetti E, et al. - Nature Communications

https://www.ncbi.nlm.nih.gov/pubmed/29133956

Promoter methylation of the mgat3 and bach2 genes correlates with the composition of the immunoglobulin g glycome in inflammatory bowel disease.

Klasic M, et al. - Clinical Epigenetics

https://www.ncbi.nlm.nih.gov/pubmed/29991969

Glycosylation of immunoglobulin G associates with clinical features of inflammatory bowel diseases.

Simurina M, et al. - Gastroenterology

https://www.ncbi.nlm.nih.gov/pubmed/29309774

The association between subclass-specific igg fc n-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations.

Liu JN, et al. - Journal of Human Hypertension

https://www.ncbi.nlm.nih.gov/pubmed/29867134

Glycosylation profile of immunoglobulin g is cross-sectionally associated with cardiovascular disease risk score and subclinical atherosclerosis in two independent cohorts.

Menni C, et al. - Circulation Research

https://www.ncbi.nlm.nih.gov/pubmed/29535164

Genome-wide association study on immunoglobulin g glycosylation patterns.

Wahl A, et al. - Frontiers in Immunology

https://www.ncbi.nlm.nih.gov/pubmed/29535710

The sweet spot for biologics: recent advances in characterization of biotherapeutic glycoproteins.

O'Flaherty R, et al. - Expert Review of Proteomics

https://www.ncbi.nlm.nih.gov/pubmed/29130774

Igg glycan patterns are associated with type 2 diabetes in independent European populations.

Lemmers RFH, et al. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/28668296

Igg glycosylation and DNA methylation are interconnected with smoking.

Wahl A, et al. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/29055820

Increased central adiposity is associated with pro-inflammatory immunoglobulin g n-glycans.

Russell AC, et al. - Immunobiology

https://www.ncbi.nlm.nih.gov/pubmed/30446335

Immunoglobulin G glycosylation in aging and diseases.

Gudelj I, et al. - Cell Immunol

https://www.ncbi.nlm.nih.gov/pubmed/30107893

2017

Ubiquitous importance of protein glycosylation.

Krištić J, et al. - Methods in Molecular Biology

https://www.ncbi.nlm.nih.gov/pubmed/27743354

The n-glycosylation of immunoglobulin g as a novel biomarker of Parkinson's disease.

Russell AC, et al. - Glycobiology

https://www.ncbi.nlm.nih.gov/pubmed/28334832

Connecting genetic risk to disease end points through the human blood plasma proteome.

Suhre K, et al. - Nature Communications

https://www.ncbi.nlm.nih.gov/pubmed/28240269

Multivariate discovery and replication of five novel loci associated with immunoglobulin g n-glycosylation.

Shen X, et al. - Nature Communications

https://www.ncbi.nlm.nih.gov/pubmed/28878392

Effects of statins on the immunoglobulin g glycome.

Keser T, et al. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/28263871

Estrogens regulate glycosylation of igg in women and men.

Ercan A, et al. - JCI Insight, The Journal of Clinical Investigation

https://www.ncbi.nlm.nih.gov/pubmed/28239652

Immunoglobulin g n-glycans as potential postgenomic biomarkers for hypertension in the Kazakh population.

Gao Q, et al. - Omics: a Journal of Integrative Biology

https://www.ncbi.nlm.nih.gov/pubmed/28692416

2016

The association between low back pain and composition of igg glycome.

Freidin MB, et al. - Scientific Reports

https://www.ncbi.nlm.nih.gov/pubmed/27229623

Glycosylation of plasma igg in colorectal cancer prognosis.

Theodoratou E, et al. - Clinical Cancer Research

https://www.ncbi.nlm.nih.gov/pubmed/27302279

IgG glycome in colorectal cancer.

Vuckovic F, et al. - Reports

https://www.ncbi.nlm.nih.gov/pubmed/26831718

Precision medicine that transcends genomics: glycans as integrators of genes and environment.

Lauc G - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/27155579

The association between glycosylation of immunoglobulin g and hypertension: a multiple ethnic cross-sectional study.

Wang Y, et al. - Medicine

https://www.ncbi.nlm.nih.gov/pubmed/27124023

Profiling igg n-glycans as potential biomarker of chronological and biological ages: a community-based study in a han Chinese population.

Yu X, et al. - Medicine

https://www.ncbi.nlm.nih.gov/pubmed/27428197

Effects of allergic diseases and age on the composition of serum igg glycome in children.

Pezer M, et al. - Scientific Reports

https://www.ncbi.nlm.nih.gov/pubmed/27616597

High-throughput analysis of immunoglobulin g glycosylation.

Trbojevic-Akmacic I, et al. - Expert Review of Proteomics

https://www.ncbi.nlm.nih.gov/pubmed/27043342

Exploring the molecular basis of age-related disease comorbidities using a multi-omics graphical model.

Zierer J, et al. - Scientific Reports

https://www.ncbi.nlm.nih.gov/pubmed/27886242

Glycosylation profile of igg in moderate kidney dysfunction.

Barrios C, et al. - JASN, Journal of the American Society of Nephrology

https://www.ncbi.nlm.nih.gov/pubmed/26185202

Mechanisms of disease: the human n-glycome.

Lauc G, et al. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/26500099

2015

Integration of 'omics' data in aging research: from biomarkers to systems biology.

Zierer J, et al. - Aging Cell

https://www.ncbi.nlm.nih.gov/pubmed/26331998

Estimation of human age using n-glycan profiles from bloodstains.

Gudelj I, et al. - International Journal of Legal Medicine

https://www.ncbi.nlm.nih.gov/pubmed/25787342

Inflammatory bowel disease associates with proinflammatory potential of the immunoglobulin g glycome.

Trbojevic Akmacic I, et al. - Inflammatory Bowel Diseases

https://www.ncbi.nlm.nih.gov/pubmed/25895110

Association of systemic lupus erythematosus with decreased immunosuppressive potential of the igg glycome.

Vuckovic F, et al. - Arthritis & Rheumatology

https://www.ncbi.nlm.nih.gov/pubmed/26200652

2014

Glycans - the third revolution in evolution.

Lauc G, et al. - Frontiers in Genetics

https://www.ncbi.nlm.nih.gov/pubmed/24904645

Comparative performance of four methods for high-throughput glycosylation analysis of immunoglobulin g in genetic and epidemiological research.

Huffman JE, et al. - Molecular & Cellular Proteomics

https://www.ncbi.nlm.nih.gov/pubmed/24719452

Key Publication

Glycans are a novel biomarker of chronological and biological ages.

Kristic J, et al. - The Journals of Gerontology, Series A

https://www.ncbi.nlm.nih.gov/pubmed/24325898

Changes in igg and total plasma protein glycomes in acute systemic inflammation.

Novokmet M, et al. - Scientific Reports

https://www.ncbi.nlm.nih.gov/pubmed/24614541

Epigenetic regulation of glycosylation is the quantum mechanics of biology.

Lauc G, et al. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/23999089

The association between galactosylation of immunoglobulin g and body mass index.

Nikolac Perkovic M, et al. - Progress in Neuro-Psychopharmacology & Biological Psychiatry

https://www.ncbi.nlm.nih.gov/pubmed/24012618

The role of glycosylation in ibd.

Theodoratou E, et al. - Nature Reviews Gastroenterology & Hepatology

https://www.ncbi.nlm.nih.gov/pubmed/24912389

2013

High-throughput igg fc n-glycosylation profiling by mass spectrometry of glycopeptides.

Pucic Bakovic M, et al. - Journal of Proteome Research

https://www.ncbi.nlm.nih.gov/pubmed/23298168

Genomics and epigenomics of the human glycome.

Zoldos V, et al. - Glycoconjugate Journal

https://www.ncbi.nlm.nih.gov/pubmed/22648057

Loci associated with n-glycosylation of human immunoglobulin g show pleiotropy with autoimmune diseases and haematological cancers.

Lauc G, et al. - PLOS Genetics

https://www.ncbi.nlm.nih.gov/pubmed/23382691

Glycomics meets genomics, epigenomics and other high throughput omics for system biology studies.

Zoldos V, et al. - Current Opinion in Chemical Biology

https://www.ncbi.nlm.nih.gov/pubmed/23287290

Glycosylation of immunoglobulin G: role of genetic and epigenetic influences.

Menni C, et al. - PLOS ONE

https://www.ncbi.nlm.nih.gov/pubmed/24324808

Omics technologies and the study of human ageing.

Valdes AM, et al. - Nature Reviews Genetics

https://www.ncbi.nlm.nih.gov/pubmed/23938363

2012

Changes in plasma and igg n-glycome during childhood and adolescence.

Pucic M, et al. - Glycobiology

https://www.ncbi.nlm.nih.gov/pubmed/22727214

The future of glycoscience.

Lauc G. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/22727214

Alternative glycosylation modulates function of igg and other proteins - implications on evolution and disease.

Gornik O, et al. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/22183029

2011

Evolutional and clinical implications of the epigenetic regulation of protein glycosylation.

Horvat T, et al. - Clinical Epigenetics

https://www.ncbi.nlm.nih.gov/pubmed/22704355

High throughput isolation and glycosylation analysis of igg-variability and heritability of the igg glycome in three isolated human populations.

Pucic M, et al. - Molecular & Cellular Proteomics

https://www.ncbi.nlm.nih.gov/pubmed/21653738

High throughput plasma n-glycome profiling using multiplexed labelling and uplc with fluorescence detection.

Knezevic A, et al. - The Analyst

https://www.ncbi.nlm.nih.gov/pubmed/21956149

Polymorphisms in b3gat1, slc9a9 and mgat5 are associated with variation within the human plasma n-glycome of 3533 european adults.

Huffman JE, et al. - Human Molecular Genetics

https://www.ncbi.nlm.nih.gov/pubmed/21908519

Screening novel biomarkers for metabolic syndrome by profiling human plasma n-glycans in Chinese han and Croatian populations.

Lu JP, et al. - Journal of Proteome Research

https://www.ncbi.nlm.nih.gov/pubmed/21939225

2010

Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma n-glycans.

Knezevic A, et al. - Glycobiology

https://www.ncbi.nlm.nih.gov/pubmed/20356825

Protein glycosylation-an evolutionary crossroad between genes and environment.

Lauc G, et al. - Molecular BioSystems

https://www.ncbi.nlm.nih.gov/pubmed/20957246

Epigenetic regulation of protein glycosylation.

Zoldos V, et al. - Biomolecular Concepts

https://www.ncbi.nlm.nih.gov/pubmed/25962001

Complex genetic regulation of protein glycosylation.

Lauc G, et al. - Molecular BioSystems

https://www.ncbi.nlm.nih.gov/pubmed/20094651

Genomics meets glycomics-the first gwas study of human n-glycome identifies hnf1α as a master regulator of plasma protein fucosylation.

Lauc G, et al. - PLOS Genetics

https://www.ncbi.nlm.nih.gov/pubmed/21203500

2009

Stability of n-glycan profiles in human plasma.

Gornik O, et al. - Glycobiology

https://www.ncbi.nlm.nih.gov/pubmed/19726492

Epigenetic regulation of glycosylation could be a mechanism used by complex organisms to compete with microbes on an evolutionary scale.

Lauc G, et al. - Medical Hypotheses

https://www.ncbi.nlm.nih.gov/pubmed/19560282

Variability, heritability and environmental determinants of human plasma n-glycome.

Knezevic A, et al. - Journal of Proteome Research

https://www.ncbi.nlm.nih.gov/pubmed/19035662

2008

Glycosylation of serum proteins in inflammatory diseases.

Gornik O, et al. - Disease Markers

https://www.ncbi.nlm.nih.gov/pubmed/19126970

2006

Sweet secret of the multicellular life.

Lauc G. - Biochimica et Biophysica Acta

https://www.ncbi.nlm.nih.gov/pubmed/16431025

2004

Stress causes tissue-specific changes in the sialyltransferase activity.

Dabelic S, et al. - Zeitschrift fur Naturforschung C, A Journal of Biosciences

https://www.ncbi.nlm.nih.gov/pubmed/15241940

1999

Fucosylation of igg heavy chains is increased in rheumatoid arthritis.

Gornik I, et al. - Clinical Biochemistry

https://www.ncbi.nlm.nih.gov/pubmed/10638942

Purification and maldi-ms characterization of stressin, a stress-associated glycoprotein.

Lauc G, et al. - Biological Chemistry

https://www.ncbi.nlm.nih.gov/pubmed/10355630

1998

Fucosylation and galactosylation of igg heavy chains differ between acute and remission phases of juvenile chronic arthritis.

Flögel M, et al. - Clinical Chemistry and Laboratory Medicine

https://www.ncbi.nlm.nih.gov/pubmed/9594046

1996

Changes of glycoprotein patterns in sera of humans under stress.

Barisic K, et al. - European Journal of Clinical Chemistry and Clinical Biochemistry

https://www.ncbi.nlm.nih.gov/pubmed/8833640

Publications

Immunoglobulin G glycome composition in transition from premenopause to postmenopause

Altered IgG glycosylation at COVID-19 diagnosis predicts disease severity

A Transient Expression System with Stably Integrated CRISPR-dCas9 Fusions for Regulation of Genes Involved in Immunoglobulin G Glycosylation

A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk

Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India

Investigation of the causal relationships between human IgG N-glycosylation and twelve common diseases associated with changes in the IgG N-glycome

Effects of Estradiol on Immunoglobulin G Glycosylation: Mapping of the Downstream Signaling Mechanism

Targeting B cells in the pre-phase of systemic autoimmunity globally interferes with autoimmune pathology

Plasma N-glycome shows continuous deterioration as the diagnosis of insulin resistance approaches

Extensive weight loss reduces glycan age by altering IgG N-glycosylation

A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection

N-glycosylation of immunoglobulin G predicts incident hypertension

Systems Glycobiology: Immunoglobulin G Glycans as Biomarkers and Functional Effectors in Aging and Diseases

Immunoglobulin G glycome composition in transition from pre-menopause to menopause

Composition of the immunoglobulin G glycome associates with the severity of COVID-19

Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases

Minimal B Cell Extrinsic IgG Glycan Modifications of Pro- and Anti-Inflammatory IgG Preparations in vivo

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

Searching for glycomic biomarkers for predicting resilience and vulnerability in a rat model of posttraumatic stress disorder

Effects of estradiol on biological age measured using the glycan age index

Biomarkers of biological age as predictors of COVID-19 disease severity

Plasma n-glycans as emerging biomarkers of cardiomatabolic risk: a prospective investigation in the epic-potsdam cohort study

Global variability of the human IgG glycome

Glycomics for type 2 diabetes biomarker discovery: promise of immunoglobulin g subclass-specific fragment crystallizable n-glycosylation in the Uyghur population.

N-glycan analysis by ultra-performance liquid chromatography and capillary gel electrophoresis with fluorescent labelling.

Supplementation with the sialic acid precursor n-acetyl-d-mannosamine breaks the link between obesity and hypertension.

Association of the IgG N-glycome with the course of kidney function in type 2 diabetes

Inflammatory bowel disease - glycomics perspective.

Translational glycobiology: from bench to bedside.

Comprehensive n-glycosylation analysis of immunoglobulin g from dried blood spots

Molecular pathways mediating immunosuppression in response to prolonged intensive physical training, low-energy availability, and intensive weight loss.

Altered n-glycosylation profiles as potential biomarkers and drug targets in diabetes.

Type 2 diabetes mellitus is associated with the immunoglobulin g n-glycome through putative proinflammatory mechanisms in an Australian population.

Intense physical exercise indicates an anti-inflammatory change in igg n-glycosylation profile

Next-generation (glycomic) biomarkers for cardiometabolic health: a community-based study of immunoglobulin g n-glycans in a Chinese Han population.

Breaking the glyco-code of HIV persistence and immunopathogenesis.

N-glycosylation patterns of plasma proteins and immunoglobulin g in chronic obstructive pulmonary disease.

Low galactosylation of igg associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up.

The changes of immunoglobulin G n-glycosylation in blood lipids and dyslipidaemia.

Frontline Science: plasma and immunoglobulin g galactosylation associate with HIV persistence during antiretroviral therapy.

Deep molecular phenotypes link complex disorders and physiological insult to CPG methylation.

Network inference from glycoproteomics data reveals new reactions in the igg glycosylation pathway.

Promoter methylation of the mgat3 and bach2 genes correlates with the composition of the immunoglobulin g glycome in inflammatory bowel disease.

Glycosylation of immunoglobulin G associates with clinical features of inflammatory bowel diseases.

The association between subclass-specific igg fc n-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations.

Glycosylation profile of immunoglobulin g is cross-sectionally associated with cardiovascular disease risk score and subclinical atherosclerosis in two independent cohorts.

Genome-wide association study on immunoglobulin g glycosylation patterns.

The sweet spot for biologics: recent advances in characterization of biotherapeutic glycoproteins.

Igg glycan patterns are associated with type 2 diabetes in independent European populations.

Igg glycosylation and DNA methylation are interconnected with smoking.

Increased central adiposity is associated with pro-inflammatory immunoglobulin g n-glycans.

Immunoglobulin G glycosylation in aging and diseases.

Ubiquitous importance of protein glycosylation.

The n-glycosylation of immunoglobulin g as a novel biomarker of Parkinson's disease.

Connecting genetic risk to disease end points through the human blood plasma proteome.

Multivariate discovery and replication of five novel loci associated with immunoglobulin g n-glycosylation.

Effects of statins on the immunoglobulin g glycome.

Estrogens regulate glycosylation of igg in women and men.

Immunoglobulin g n-glycans as potential postgenomic biomarkers for hypertension in the Kazakh population.

The association between low back pain and composition of igg glycome.

Glycosylation of plasma igg in colorectal cancer prognosis.

IgG glycome in colorectal cancer.

Precision medicine that transcends genomics: glycans as integrators of genes and environment.

The association between glycosylation of immunoglobulin g and hypertension: a multiple ethnic cross-sectional study.

Profiling igg n-glycans as potential biomarker of chronological and biological ages: a community-based study in a han Chinese population.

Effects of allergic diseases and age on the composition of serum igg glycome in children.

High-throughput analysis of immunoglobulin g glycosylation.

Exploring the molecular basis of age-related disease comorbidities using a multi-omics graphical model.

Glycosylation profile of igg in moderate kidney dysfunction.

Mechanisms of disease: the human n-glycome.

Integration of 'omics' data in aging research: from biomarkers to systems biology.

Estimation of human age using n-glycan profiles from bloodstains.

Inflammatory bowel disease associates with proinflammatory potential of the immunoglobulin g glycome.

Association of systemic lupus erythematosus with decreased immunosuppressive potential of the igg glycome.

Glycans - the third revolution in evolution.

Comparative performance of four methods for high-throughput glycosylation analysis of immunoglobulin g in genetic and epidemiological research.

Glycans are a novel biomarker of chronological and biological ages.

Changes in igg and total plasma protein glycomes in acute systemic inflammation.

Epigenetic regulation of glycosylation is the quantum mechanics of biology.

Low galactosylation of igg associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up.