Science Behind

“Glycans are directly involved in the pathophysiology of every major disease… Additional knowledge from glycoscience will be needed to realize the goals of personalized medicine and to take advantage of the substantial investments in human genome and proteome research and its impact on human health.”

— US National Academies, 2012


What are glycans?
Glycans are sugar molecules that surround and modify proteins in your body. They respond to your lifestyle choices and indicate the inflammatory state of your immune system, which in turn determines to your biological age.

Glycans have a large influence on your unique biology and are regulated almost equally by our genes on one side and environment and lifestyle choices on the other.
How do Glycans affect health and ageing?
Glycans play a vital role in keeping us healthy but are also involved in most major diseases. As we age, the balance of pro-inflammatory and anti-inflammatory glycans in our body changes.

Various inflammatory effectors like excessive or unsuitable diet or fitness regimen, hormone changes, surrounding environment, ethnic background, etc. can cause an imbalance between pro and anti-inflammatory glycans. This leads to low-grade systemic inflammation, which can speed up the process of ageing and increase the risk for many diseases.
How does GlycanAge determine biological Age?
GlycanAge determines your biological age by looking at the state of your immune system and inflammation.

We analyse the glycans attached to the most common antibody in your blood, called Immunoglobulin G or IgG.

The type of glycans attached to IgG are able to change the function of IgG from pro-inflammatory to anti-inflammatory and vice versa.

We need both functions for a strong immune system, but the balance between them will determine our general health status and consequentially our biological age.

Our Scientists & Advisors

Our Scientific Advisory Board includes scientists, researchers, doctors, and authors across the fields of glycobiology, immunology, longevity and molecular biology, including lead figures from the Human Glycome Project.

They lead labs, teach at world-renowned academic institutions, and have hundreds of publications in peer-reviewed scientific journals.

The ongoing research allows us to not only provide the most accurate test of biological age, but also to keep adding to the insights we can deliver to you.

With over 100,000 participants worldwide, and 20 years of experience we are at the forefront of glycoscience globally.

  • Prof. Sc.D Gordan Lauc
    Prof. Sc.D Gordan Lauc Molecular Biologist
  • Prof. Sc.D Ronald Schnaar
    Prof. Sc.D Ronald Schnaar Pharmacologist, Molecular Biologist
  • PhD. Bill Andrews
    PhD. Bill Andrews Scientist, Biologist and Gerontologist
  • Prof. Sc.D Vlatka Zoldoš
    Prof. Sc.D Vlatka Zoldoš Epigeneticist
  • PhD. Marija Pezer
    PhD. Marija Pezer Scientist, Molecular Biologist
  • Prof. Sc.D Dragan Primorac
    Prof. Sc.D Dragan Primorac Physician, Geneticist, Forensic Scientist

Straight from the lab

Health

An Old Cure for a New Cause – Weight Loss as an Anti-Ageing Strategy

Tired of anti-ageing advice that just does not work? Try a science-backed approach, powered by glycans

By Ana Cindrić
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Health

Prof Azra Raza's Lecture for The Human Glycome Project Researchers

Azra Raza is an oncologist, and professor of medicine, and director of the Myelodysplastic Syndrome Center at Columbia University, New York. She has dedicated almost her entire life to fighting cancer and discovering ways to prevent it by detecting the first cancer cell in the human body.

By The GlycanAge Team
Read full article
Glycoscience

Women Age Twice as Fast During Perimenopause

Women's biological age increases significantly during their transition from perimenopause to menopause.

By Prof Gordan Lauc, PhD
Read full article