Science Behind

“Glycans are directly involved in the pathophysiology of every major disease… Additional knowledge from glycoscience will be needed to realize the goals of personalized medicine and to take advantage of the substantial investments in human genome and proteome research and its impact on human health.”

— US National Academies, 2012

What are glycans?
Glycans are sugar molecules that surround and modify proteins in your body. They respond to your lifestyle choices and indicate the inflammatory state of your immune system, which in turn determines to your biological age.

Glycans have a large influence on your unique biology and are regulated almost equally by our genes on one side and environment and lifestyle choices on the other.
Cell illustration
How do Glycans affect health and ageing?
Glycans play a vital role in keeping us healthy but are also involved in most major diseases. As we age, the balance of pro-inflammatory and anti-inflammatory glycans in our body changes.

Various inflammatory effectors like excessive or unsuitable diet or fitness regimen, hormone changes, surrounding environment, ethnic background, etc. can cause an imbalance between pro and anti-inflammatory glycans. This leads to low-grade systemic inflammation, which can speed up the process of ageing and increase the risk for many diseases.
How does GlycanAge determine biological Age?
GlycanAge determines your biological age by looking at the state of your immune system and inflammation.

We analyse the glycans attached to the most common antibody in your blood, called Immunoglobulin G or IgG.

The type of glycans attached to IgG are able to change the function of IgG from pro-inflammatory to anti-inflammatory and vice versa.

We need both functions for a strong immune system, but the balance between them will determine our general health status and consequentially our biological age.

Our Scientists & Advisors

Our Scientific Advisory Board includes scientists, researchers, doctors, and authors across the fields of glycobiology, immunology, longevity and molecular biology, including lead figures from the Human Glycome Project.

They lead labs, teach at world-renowned academic institutions, and have hundreds of publications in peer-reviewed scientific journals.

The ongoing research allows us to not only provide the most accurate test of biological age, but also to keep adding to the insights we can deliver to you.

With over 100,000 participants worldwide, and 20 years of experience we are at the forefront of glycoscience globally.

  • Prof. Sc.D Gordan Lauc
    Prof. Sc.D Gordan Lauc Molecular Biologist
  • PhD. Bill Andrews
    PhD. Bill Andrews Scientist, Biologist and Gerontologist
  • Prof. Sc.D Ronald Schnaar
    Prof. Sc.D Ronald Schnaar Pharmacologist, Molecular Biologist
  • Prof. Sc.D Vlatka Zoldoš
    Prof. Sc.D Vlatka Zoldoš Epigeneticist
  • Prof. Sc.D Dragan Primorac
    Prof. Sc.D Dragan Primorac Physician, Geneticist, Forensic Scientist
  • PhD. Marija Pezer
    PhD. Marija Pezer Scientist, Molecular Biologist
  • PhD. Marina Martinić Kavur Scientist, Head of Science Communications

Straight from the lab

Magazine image Health

What Can Low Back Pain Tell Us About Our Health – and How to Manage It?

Changes in glycans point to chronic inflammation as a possible long-term underlying cause of low back pain and fatigue, even if there is no injury to the tissue.

By Ph. D. Julija Jurić
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Magazine image Health

Conducting Your Own Self-experiment in Order to Improve Your Biological Age

Ageing, whilst wholly a natural process, isn’t necessarily something we would want to embrace. Advancing age is a risk factor for heart disease, declining metabolic function, certain cancers, and a myriad of other conditions of poor health.

By Jenna Macciochi
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How to Slow Down Skin Ageing?

Radiant, great-looking skin is often considered evidence of overall good health. Internal imbalances in sex hormones that happen with ageing can disrupt delicate harmony in the body and cause skin changes that seemingly give a person an older appearance. Hormone replacement with bioidentical hormones stands out as an effective way to prevent accelerated skin ageing.

By Ph. D. Julija Jurić
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