Biological age and longevity blog: glycans, inflammation, and healthy aging · Page 28

Can Glycans Predict the Loss of Kidney Function

Chronic kidney failure is one of the most common and debilitating complications of diabetes. Changes in glycosylation of immunoglobulin G (IgG) accompany biological ageing and regulates inflammation in diabetes – a process that participates in kidney function decline. A new study looks at the correlation between kidne…

Published:
June 9, 2020 Reading time:
5 minutes

Sialylation of Immunoglobulin E Is a Determinant of Allergic Pathogenicity

Immunoglobulin E (IgE) is a key molecule in allergies - the over-reaction of our immune system to non-harmful antigens from our surroundings. Upon sensitization, which happens at initial contact with antigen (in this case – allergen), allergen-specific IgE is synthesized and sits on the surface of cells (mastocytes an…

Published:
May 21, 2020 Reading time:
5 minutes

GlycanAge - the Best Biomarker of Biological Age

Over 10 years of research on over 100,000 people condensed in 13 min presentation of Prof Gordan Lauc at the Longevity Leaders Virtual 2020. Check this video for an introduction about glycans and their role in ageing and disease.

Published:
May 19, 2020 Reading time:
5 minutes

Glycans Are Crucial for the Response to Sars Cov-2 Infection

Each virus possesses a specific entry protein that acts as a key, unlocking the gates to the host cells. This viral entry protein usually binds to one of the host proteins, “the lock”, and such interactions are crucial for the infection and propagation of the virus [1]. Coronaviruses, in particular, are notoriously ve…

Published:
May 18, 2020 Reading time:
10 minutes

How Does GlycanAge Compare to Methylation as a Biomarker for Biological Age?

Published:
May 11, 2020

Glycans as Biomarkers of Ageing and Age-Related Diseases

It is general knowledge that the prevalence of chronic and inflammatory diseases increases with age. However, as biological ageing does not always correspond to chronological age, many younger individuals are also prone to developing chronic diseases or severe COVID-19 disease. What are glycans? How to change your bio…

Published:
May 8, 2020 Reading time:
5 minutes

Obesity - How Dangerous Is It Really?

Obesity, known as a BMI of 30 and above, is one of the major global health problems. Recently, with the ongoing global spreading of COVID-19, obesity is the most talked-about risk factor of the COVID-19 severity, alongside with old age and cardiometabolic issues. Moreover, the US Centre for Disease Control and Prevent…

Published:
April 29, 2020 Reading time:
5 minutes

How to Collect My Blood Sample

* Make sure you read the Limitations & Special Considerations on your Instructions sheet before you start.

Published:
April 17, 2020 Reading time:
5 minutes

Boost Your Immune System, Change Your Glycome

As the beginning of 2020 led the world into a new type of concern, the pandemics of COVID-19, we were bombarded with advice on how to keep ourselves safe. All the warnings came in the sense of “wash your hands regularly”, “do not touch your face” (and suddenly we became aware that this is a habit of most of us), socia…

Published:
April 16, 2020 Reading time:
5 minutes

Sweet Beginnings: How Sugars Help to Build Your Brain

The creation of a complete human being from a single cell is one of the most mind-boggling transformations in nature. An almost immeasurable number of molecular events must be precisely coordinated and each of the steps has to occur in the right sequence and at exactly the right time to go from a single, microscopic c…

Published:
April 12, 2020 Reading time:
5 minutes

Measure, Normalise, Analyse

Glycans are complex sugar molecules that are present on the majority of proteins in the human body. As such, glycans have shown great potential as biomarkers of both biological and chronological ages, as well as various diseases, including cancer and autoimmune diseases. Large sample sizes need to be measured for stud…

Published:
April 7, 2020 Reading time:
5 minutes

Sweet Brain O'Mine: How Sugars Help You Think!

Synaptic transmission, synaptic excitability, neuronal action potentials, neuronal firing, are just a bunch of fancy terms to describe the amazing phenomenon of chemical information streaming and flowing within your brain cells. You might have been told not to skip breakfast, since glucose fuels your mind and, along w…

Published:
April 7, 2020 Reading time:
5 minutes