Biological age and longevity blog: glycans, inflammation, and healthy aging · Page 23
Explore the latest insights and research in GlycanAge testing, alongside expert advice and personal journeys that dive into the fascinating intersection of science, lifestyle, and health.
Sweet Brain O'Mine: How Sugars Help You Think!
Synaptic transmission, synaptic excitability, neuronal action potentials, neuronal firing, are just a bunch of fancy terms to describe the amazing phenomenon of chemical information streaming and flowing within your brain cells. You might have been told not to skip breakfast, since glucose fuels your mind and, along w…
Published:April 7, 2020
Reading time:5 minutes
Glycosylation Profile of Sars-Cov-2 Spike Protein
A novel human coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, is currently one of the major health problems in the world. SARS-CoV-2 causes a respiratory illness named Coronavirus disease (COVID-19) and so far, we have 1 276 732 reported cases of COVID-19 and 56…
Published:April 6, 2020
Reading time:5 minutes
Understanding Glycans in COVID-19 Drug Design
Coronaviruses have been around for centuries. The 21st century brought three known to cause severe human disease and global transmission concerns: SARS-CoV in 2002; MERS-CoV in 2012; and most recently SARS-CoV-2, which arose in 2019, causing an international pandemic. Given the substantial morbidity and mortality rate…
Published:April 2, 2020
Reading time:5 minutes
Mucin 4 Glycoprotein Appears to Play an Important Role in Coronavirus Disease
Many surfaces of our body, including the surface of the respiratory system (from the nose to the lung), eyes, ears, intestine and others, are covered by a layer called mucus. This mucus layer serves as the body's very first line of defence against pathogens (e.g. bacteria, viruses). The main components of mucus beside…
Published:April 2, 2020
Reading time:5 minutes
Glycans in Drug Discovery - HIV Glycopeptide Antigens
Glycoproteins found at the surface of several viruses are called viral envelope glycoproteins and they are great targets for virus neutralisation. Synthetic glycopeptides that mimic natural HIV envelope glycoproteins have been considered as anti-HIV therapy. Viral envelope glycoproteins, such as gp120 in HIV-1, have g…
Published:April 2, 2020
Reading time:5 minutes
Glycans as Biomarkers for Liver and Pancreatic Cancer
Cancer is responsible for an estimate of 9.6 million deaths in 2018, making it leading cause of death in the world (about 1 in 6 deaths is due to cancer). Lung, stomach, liver, colon and breast cancers have the highest mortality rates among the patients. Due to that, the need for biomarkers that can determine the risk…
Published:April 2, 2020
Reading time:5 minutes
COVID19 Severity – Are Smokers at Risk?
Beginning of 2020 will be known for the pandemic of COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2). Symptoms can be mild to severe, and all of us are aware of guidelines that should be followed to prevent spreading the virus and getting sick.
Published:April 2, 2020
Reading time:5 minutes
The Importance of IgG Glycosylation in Drug Development
Antibodies can be used preventatively as vaccines, but also as post-diagnosis treatment for many human diseases including cancer and immunologic illnesses. Both the production and market of therapeutic antibodies have undergone exponential growth in the past few years, and this trend is not expected to stop anytime so…
Published:April 1, 2020
Reading time:5 minutes
Biomarkers of Biological Age as Predictors of COVID-19 Disease Severity
Early epidemiological studies suggest the most important predictor of severity of COVID-19 disease course is age. Pre-existing conditions, including diabetes, CVD, hypertension, obesity and other consequences of an unhealthy lifestyle are also associated with increased mortality, indicating that the biological age is …
Published:March 28, 2020
Reading time:10 minutes
The Sars-Cov-2 Spike Protein Is Densely Glycosylated
The spike protein is a trimeric protein on the surface of the SARS-CoV-2. This protein gives the whole viral family a crown-like appearance by forming spikes on their surface, hence their name – corona (Latin for crown). The spike protein mediates receptor recognition and membrane fusion during host cell infection. Du…
Published:March 26, 2020
Reading time:5 minutes
Glycans in Nanotechnology
Nanotechnology is technology, science and engineering conducted at the nanoscale, which is about 1 to 100 nanometers, to create, manipulate, and characterize structures on those scales. As it is shown, glycans are applicable biomarkers for medical diagnostic. It is known that material properties are changed on nanosca…
Published:March 26, 2020
Reading time:5 minutes
Have Glycans Finally Found a Place in Medicine?
Complex sugar molecules called glycans are an essential component to life as we know it since they are estimated to be the most abundant class of organic molecules on Earth. They are present in all domains of life, taking different shapes and sizes – from a single monosaccharide to the complex polysaccharides containi…
Published:March 26, 2020
Reading time:5 minutes