Biological age and longevity blog: glycans, inflammation, and healthy aging · Page 26

Glycans as Biomarkers for Liver and Pancreatic Cancer

Cancer is responsible for an estimate of 9.6 million deaths in 2018, making it leading cause of death in the world (about 1 in 6 deaths is due to cancer). Lung, stomach, liver, colon and breast cancers have the highest mortality rates among the patients. Due to that, the need for biomarkers that can determine the risk…

Published:
April 2, 2020 Reading time:
5 minutes

COVID19 Severity – Are Smokers at Risk?

Beginning of 2020 will be known for the pandemic of COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2). Symptoms can be mild to severe, and all of us are aware of guidelines that should be followed to prevent spreading the virus and getting sick.

Published:
April 2, 2020 Reading time:
5 minutes

The Importance of IgG Glycosylation in Drug Development

Antibodies can be used preventatively as vaccines, but also as post-diagnosis treatment for many human diseases including cancer and immunologic illnesses. Both the production and market of therapeutic antibodies have undergone exponential growth in the past few years, and this trend is not expected to stop anytime so…

Published:
April 1, 2020 Reading time:
5 minutes

Biomarkers of Biological Age as Predictors of COVID-19 Disease Severity

Early epidemiological studies suggest the most important predictor of severity of COVID-19 disease course is age. Pre-existing conditions, including diabetes, CVD, hypertension, obesity and other consequences of an unhealthy lifestyle are also associated with increased mortality, indicating that the biological age is …

Published:
March 28, 2020 Reading time:
10 minutes

The Sars-Cov-2 Spike Protein Is Densely Glycosylated

The spike protein is a trimeric protein on the surface of the SARS-CoV-2. This protein gives the whole viral family a crown-like appearance by forming spikes on their surface, hence their name – corona (Latin for crown). The spike protein mediates receptor recognition and membrane fusion during host cell infection. Du…

Published:
March 26, 2020 Reading time:
5 minutes

Glycans in Nanotechnology

Nanotechnology is technology, science and engineering conducted at the nanoscale, which is about 1 to 100 nanometers, to create, manipulate, and characterize structures on those scales. As it is shown, glycans are applicable biomarkers for medical diagnostic. It is known that material properties are changed on nanosca…

Published:
March 26, 2020 Reading time:
5 minutes

Have Glycans Finally Found a Place in Medicine?

Complex sugar molecules called glycans are an essential component to life as we know it since they are estimated to be the most abundant class of organic molecules on Earth. They are present in all domains of life, taking different shapes and sizes – from a single monosaccharide to the complex polysaccharides containi…

Published:
March 26, 2020 Reading time:
5 minutes

Intestinal Microbiota and Glycosylation

The human colon is extensively colonized with bacteria, fungi, and viruses. This colony of commensal, symbiotic and pathogenic microorganisms remains stable throughout the years but can change in some diseases (e.g., inflammatory bowel disease, HIV infection) and as a result of different environmental factors (e.g., d…

Published:
March 25, 2020 Reading time:
5 minutes

Glycosylation in Neurodegeneration

Since our world is rapidly ageing, neurodegenerative diseases, affecting mostly the elderly population, represent one of the most common causes of death. They are associated with a wide range of rather unpleasant symptoms, such as memory loss, mood changes, tremors, hallucinations, psychosis, depression and many more.…

Published:
March 25, 2020 Reading time:
5 minutes

Glycomic Diversity of Homogenous Cell Populations

Published:
March 24, 2020

A Targeted Approach to Determining the Human Glycome

Published:
March 24, 2020

Glycomes of Cancer and Autoimmune Diseases

Published:
March 24, 2020 Reading time:
5 minutes