Predicting Vulnerability to Stress Using Glycans
Can our glycans tell us something about our vulnerability to stress?
Can our glycans tell us something about our vulnerability to stress?
To learn more about the science behind the GlycanAge® biomarker of biological age and how does it compare to DNA methylation, check this 4 min video by Prof Gordan Lauc, founder of the Genos Glycoscience Research Institute and Director of the Human Glycome Project
The glycosylation machinery inside the cell’s factories requires the coordinated action of hundreds of different enzymes working together in perfect harmony. If even one of these enzymes is not working properly, that can be a big problem.
Glycans are complex sugar molecules that are present on the majority of proteins in the human body. As such, glycans have shown great potential as biomarkers of both biological and chronological ages, as well as various diseases, including cancer and autoimmune diseases.
Detailed glycan analysis and potential post-translational modifications of the SARS-CoV-2 spike protein is very important for the development of glycoprotein-based vaccine.
We need to intensify studies on the role of glycosylation and understand the importance of these complicated structures if we want to have success in the diagnosis, treatment, and prevention of the COVID-19.
Glycoproteins found at the surface of several viruses are called viral envelope glycoproteins and they are great targets for virus neutralization.
IgG glycosylation is an important part of antibody-based drug production since it offers insights into the drug’s efficacy along with a more accurate prediction of the patient’s immune response to the drug.
The spike protein mediates receptor recognition and membrane fusion during host cell infection.
The importance of glycans in nanotechonology
Glycans, the complex sugar molecules, are an essential component of life.
One of the key players in maintaining gut microbiota homeostasis are glycoproteins called mucins.