Biological age and longevity blog: glycans, inflammation, and healthy aging · Page 21
Explore the latest insights and research in GlycanAge testing, alongside expert advice and personal journeys that dive into the fascinating intersection of science, lifestyle, and health.
Boost Your Immune System, Change Your Glycome
As the beginning of 2020 led the world into a new type of concern, the pandemics of COVID-19, we were bombarded with advice on how to keep ourselves safe. All the warnings came in the sense of “wash your hands regularly”, “do not touch your face” (and suddenly we became aware that this is a habit of most of us), socia…
Published:April 16, 2020
Reading time:5 minutes
Sweet Beginnings: How Sugars Help to Build Your Brain
The creation of a complete human being from a single cell is one of the most mind-boggling transformations in nature. An almost immeasurable number of molecular events must be precisely coordinated and each of the steps has to occur in the right sequence and at exactly the right time to go from a single, microscopic c…
Published:April 12, 2020
Reading time:5 minutes
Measure, Normalise, Analyse
Glycans are complex sugar molecules that are present on the majority of proteins in the human body. As such, glycans have shown great potential as biomarkers of both biological and chronological ages, as well as various diseases, including cancer and autoimmune diseases. Large sample sizes need to be measured for stud…
Published:April 7, 2020
Reading time:5 minutes
Sweet Brain O'Mine: How Sugars Help You Think!
Synaptic transmission, synaptic excitability, neuronal action potentials, neuronal firing, are just a bunch of fancy terms to describe the amazing phenomenon of chemical information streaming and flowing within your brain cells. You might have been told not to skip breakfast, since glucose fuels your mind and, along w…
Published:April 7, 2020
Reading time:5 minutes
Glycosylation Profile of Sars-Cov-2 Spike Protein
A novel human coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, is currently one of the major health problems in the world. SARS-CoV-2 causes a respiratory illness named Coronavirus disease (COVID-19) and so far, we have 1 276 732 reported cases of COVID-19 and 56…
Published:April 6, 2020
Reading time:5 minutes
Understanding Glycans in COVID-19 Drug Design
Coronaviruses have been around for centuries. The 21st century brought three known to cause severe human disease and global transmission concerns: SARS-CoV in 2002; MERS-CoV in 2012; and most recently SARS-CoV-2, which arose in 2019, causing an international pandemic. Given the substantial morbidity and mortality rate…
Published:April 2, 2020
Reading time:5 minutes
Mucin 4 Glycoprotein Appears to Play an Important Role in Coronavirus Disease
Many surfaces of our body, including the surface of the respiratory system (from the nose to the lung), eyes, ears, intestine and others, are covered by a layer called mucus. This mucus layer serves as the body's very first line of defence against pathogens (e.g. bacteria, viruses). The main components of mucus beside…
Published:April 2, 2020
Reading time:5 minutes
Glycans in Drug Discovery - HIV Glycopeptide Antigens
Glycoproteins found at the surface of several viruses are called viral envelope glycoproteins and they are great targets for virus neutralisation. Synthetic glycopeptides that mimic natural HIV envelope glycoproteins have been considered as anti-HIV therapy. Viral envelope glycoproteins, such as gp120 in HIV-1, have g…
Published:April 2, 2020
Reading time:5 minutes
Glycans as Biomarkers for Liver and Pancreatic Cancer
Cancer is responsible for an estimate of 9.6 million deaths in 2018, making it leading cause of death in the world (about 1 in 6 deaths is due to cancer). Lung, stomach, liver, colon and breast cancers have the highest mortality rates among the patients. Due to that, the need for biomarkers that can determine the risk…
Published:April 2, 2020
Reading time:5 minutes
COVID19 Severity – Are Smokers at Risk?
Beginning of 2020 will be known for the pandemic of COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2). Symptoms can be mild to severe, and all of us are aware of guidelines that should be followed to prevent spreading the virus and getting sick.
Published:April 2, 2020
Reading time:5 minutes
The Importance of IgG Glycosylation in Drug Development
Antibodies can be used preventatively as vaccines, but also as post-diagnosis treatment for many human diseases including cancer and immunologic illnesses. Both the production and market of therapeutic antibodies have undergone exponential growth in the past few years, and this trend is not expected to stop anytime so…
Published:April 1, 2020
Reading time:5 minutes
Biomarkers of Biological Age as Predictors of COVID-19 Disease Severity
Early epidemiological studies suggest the most important predictor of severity of COVID-19 disease course is age. Pre-existing conditions, including diabetes, CVD, hypertension, obesity and other consequences of an unhealthy lifestyle are also associated with increased mortality, indicating that the biological age is …
Published:March 28, 2020
Reading time:10 minutes