Biological age and longevity blog: glycans, inflammation, and healthy aging · Page 21

Predicting Vulnerability to Stress Using Glycans

We all react differently to stress. For example, it’s known that only 10-20% of people exposed to traumatic events will go on to develop Post-Traumatic Stress Disorder (PTSD), a severe mental health condition that dramatically impacts on people’s quality of life. This suggests that there is some diversity in the human…

Published:
July 26, 2020 Reading time:
5 minutes

It’s Official – Stress Alters the Way Brain Proteins Are Glycosylated

We all know that too much stress is bad. It has detrimental consequences for nearly all aspects of our physical and mental health. It especially impacts areas such as immune function, mood, blood pressure, and cognition. But we have known for a long time that stress also affects protein glycosylation, the process of a…

Published:
July 21, 2020 Reading time:
5 minutes

The Role of Glycans and Water in the Seasonality of COVID-19

COVID-19 seasonality is an important open question with conflicting information from different studies. At the moment we see an apparent decrease in COVID-19 severity in most parts of the northern hemisphere, but it is still not clear whether the decrease in the number of seriously ill people is due to SARS-CoV-2 seas…

Published:
July 14, 2020 Reading time:
5 minutes

Effects of Estrogens on the GlycanAge Index of Biological Age

One of the key requirements for an ageing biomarker is that it is responsive to interventions that are beneficially affecting the biology of ageing, but convincing evidence of this is still missing for many ageing biomarkers.

Published:
June 29, 2020 Reading time:
5 minutes

Can Glycans Predict the Loss of Kidney Function

Chronic kidney failure is one of the most common and debilitating complications of diabetes. Changes in glycosylation of immunoglobulin G (IgG) accompany biological ageing and regulates inflammation in diabetes – a process that participates in kidney function decline. A new study looks at the correlation between kidne…

Published:
June 9, 2020 Reading time:
5 minutes

Sialylation of Immunoglobulin E Is a Determinant of Allergic Pathogenicity

Immunoglobulin E (IgE) is a key molecule in allergies - the over-reaction of our immune system to non-harmful antigens from our surroundings. Upon sensitization, which happens at initial contact with antigen (in this case – allergen), allergen-specific IgE is synthesized and sits on the surface of cells (mastocytes an…

Published:
May 21, 2020 Reading time:
5 minutes

GlycanAge - the Best Biomarker of Biological Age

Over 10 years of research on over 100,000 people condensed in 13 min presentation of Prof Gordan Lauc at the Longevity Leaders Virtual 2020. Check this video for an introduction about glycans and their role in ageing and disease.

Published:
May 19, 2020 Reading time:
5 minutes

Glycans Are Crucial for the Response to Sars Cov-2 Infection

Each virus possesses a specific entry protein that acts as a key, unlocking the gates to the host cells. This viral entry protein usually binds to one of the host proteins, “the lock”, and such interactions are crucial for the infection and propagation of the virus [1]. Coronaviruses, in particular, are notoriously ve…

Published:
May 18, 2020 Reading time:
10 minutes

How Does GlycanAge Compare to Methylation as a Biomarker for Biological Age?

Published:
May 11, 2020

Glycans as Biomarkers of Ageing and Age-Related Diseases

It is general knowledge that the prevalence of chronic and inflammatory diseases increases with age. However, as biological ageing does not always correspond to chronological age, many younger individuals are also prone to developing chronic diseases or severe COVID-19 disease. What are glycans? How to change your bio…

Published:
May 8, 2020 Reading time:
5 minutes

Obesity - How Dangerous Is It Really?

Obesity, known as a BMI of 30 and above, is one of the major global health problems. Recently, with the ongoing global spreading of COVID-19, obesity is the most talked-about risk factor of the COVID-19 severity, alongside with old age and cardiometabolic issues. Moreover, the US Centre for Disease Control and Prevent…

Published:
April 29, 2020 Reading time:
5 minutes

How to Collect My Blood Sample

* Make sure you read the Limitations & Special Considerations on your Instructions sheet before you start.

Published:
April 17, 2020 Reading time:
5 minutes